Dienogest suppresses the activation of primordial follicles and preserves the primordial follicle stockpile for fertility in mice

Luyi Zheng; Fuminori Kimura; Di Wu; Aina Morimune; Yoko Niwa; Shizuka Mita; Kentaro Takahashi; Takashi Murakami

doi:10.1016/j.rbmo.2017.12.018

Dienogest suppresses the activation of primordial follicles and preserves the primordial follicle stockpile for fertility in mice

Luyi Zheng, Fuminori Kimura, Di Wu, Aina Morimune, Yoko Niwa, Shizuka Mita, Kentaro Takahashi, Takashi Murakami

In: Reproductive BioMedicine Online · 2018 · vol. 36(4) , pp. 371–379 · doi:10.1016/j.rbmo.2017.12.018 · PMID:29609766 · W2782553485

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Dienogest administration in mice reduced primordial follicle activation and conserved their number, potentially preserving fertility.

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References (27)

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Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study via openalex
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Cited by (1)

Exploring the Impact of Endometrioma Aspiration and Dienogest Combination Therapy on Cyst Size, Inflammatory Cytokines in Follicular Fluid and Fertility Outcomes 2023

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[1] Dienogest, a selective progestin, reduces plasma estradiol level through induction of apoptosis of granulosa cells in the ovarian dominant follicle without follicle-stimulating hormone suppression in monkeys via openalex

[2] Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study via openalex

[3] Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile via openalex

[4] Efficacy and safety of a novel oral contraceptive based on oestradiol (oestradiol valerate/dienogest): A Phase III trial via openalex

[5] New progestagens for contraceptive use via openalex

[6] Protective effect of dienogest on chemotherapy-induced reduced fertility in female rats via openalex

[7] doi:10.1016/j.jri.2009.09.002 via openalex

[8] doi:10.3109/13697137.2016.1164133 via openalex

[9] doi:10.1186/s13048-016-0246-7 via openalex

[10] doi:10.1210/en.2009-1176 via openalex

[11] doi:10.1093/humrep/14.9.2328 via openalex

[12] doi:10.1210/en.2009-0751 via openalex

[13] doi:10.1172/jci107194 via openalex

[14] doi:10.1530/rep-13-0181 via openalex

[15] doi:10.1093/molehr/gat065 via openalex

[16] doi:10.1210/er.2014-1020 via openalex

[17] doi:10.1016/j.fertnstert.2012.11.034 via openalex

[18] doi:10.1126/scitranslmed.3005402 via openalex

[19] doi:10.1016/j.cca.2014.07.029 via openalex

[20] doi:10.1371/journal.pone.0008772 via openalex

[21] doi:10.1172/jci119074 via openalex

[22] doi:10.1530/jrf.0.0880399 via openalex

[23] doi:10.1093/humupd/dmv037 via openalex

[24] doi:10.1038/nrendo.2011.224 via openalex

[25] doi:10.1007/s10735-016-9692-1 via openalex

[26] W2181155622 via openalex

[27] doi:10.1677/jme.0.0170055 via openalex