Zyklusanhängige Veränderungen der uterinen Kontraktilität bei gesunden Frauen und Patientinnen mit Dysmenorrhoe und Adenomyose/Endometriose

The study investigated cycle-dependent changes in uterine contractility using transvaginal ultrasound in 63 women: healthy controls (n=21), adenomyosis patients (n=20), and endometriosis patients (n=22), measuring contraction frequency and amplitude (myometrial pressure difference) at cycle days 1–3 and 10–12. Overall, contraction frequency was significantly higher in the midcycle than in the early follicular phase, while amplitude was significantly higher in the follicular phase than midcycle. In subgroup analyses, the follicular–midcycle amplitude difference was not significant in controls (p=0.051), but remained significant in dysmenorrhea (p=0.010) and endometriosis (p=0.007) even after Bonferroni correction. The paper relates to endometriosis and adenomyosis by directly comparing uterine contractility patterns among patients with adenomyosis and endometriosis and identifying disease-associated differences in cycle-dependent myometrial activity.

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