R Gaetje

Objectives: Endometriosis is a common gynecological disease affecting up to ~10% of women at reproductive age. Prior combined studies implied that MARVELD2 might be involved in the pathogenesis of certain malignancies. Here, 211 Han Chinese…

Endometriosis is defined as the presence of endometrium outside of uterine cavity and thought to develop through reverse menstruation of endometrial tissue into the peritoneal cavity. Endometrial cell implantation into peritoneal cavity is …

Sphingolipids are important constituents of cell membranes, which play key roles as regulatory molecules for various cellular functions. Sphingosine-1-phosphate produced by sphingosine kinase 1 (SPHK1) promotes cell proliferation, regulates…

Membrane proteins of the claudin superfamily are important components of cellular tight and adherens junctions. Although their exact function remains unclear, these proteins may play a role in tissue remodeling, a process which is associate…

Cytokeratins are a multigene family of polypeptides expressed in distinct combinations along the various routes of epithelial differentiation. In endometrial cancer and cervical intraepithelial neoplasia/cervical squamous cell carcinoma, th…

BACKGROUND: The metalloproteinases (MMPs) are a family of proteolytic enzymes involved in tissue remodeling and cell migration. Endometrial tissue remodeling proceeds during the menstrual cycle and requires a temporary and spatially balance…

The uterus is composed of different smooth muscle layers that serve various functions. First, menstrual debris is expulsed at the time of the menses. Second, sperm is transported in the preovulatory phase to maximize fertility, and third, t…

Hintergrund: Die Erweiterung der Übergangszone ("junctional Zone", JZ) in der Magnetresonanztomographie (MRI) gilt als Hauptkriterium der Adenomyose1. Da die schwere Dysmenorrhoe das Leitsymptom der Endometriose darstellt, aber nie mit eine…

The significance of retrograde menstruation as a risk factor for endometriosis has been confirmed by numerous clinical observations. Integrins mediate both cell-cell and cell-matrix adhesion, and it is therefore suspected that integrins are…

Bleeding disorders are one of the most frequent gynecological problems. The causes of bleeding disorders, and their frequency in particular, vary depending on the age of the woman affected. In premenopause and perimenopause, the most freque…

Peritoneum und das innere Genitale der Frau stammen beide vom embryonalen Zölomepithel ab. Vor diesem Hintergrund ist eine Hypothese zur Entstehung der Endometriose, dass sich diese durch Metaplasie aus dem Peritoneum entwickelt. In der emb…

OBJECTIVE: Uterine hyperperistalsis and dysperistalsis are common phenomena in endometriosis and may be responsible for reduced fertility in cases of minimal or mild extent of disease. Since a high prevalence of adenomyosis uteri has been w…

Trotz zahlreicher wissenschaftlicher Untersuchungen ist die Pathogenese der Endometriose in ihren zentralen Punkten bis heute ungeklärt. Die aufgestellten Theorien zur Entstehung werden zwar jeweils durch eine Vielzahl klinischer Beobachtun…

Endometriosis and adenomyosis show a high prevalence and can be regarded as different symptoms of a unique disease - the dislocation of basal endometrium. Diagnostic methods for detecting adenomyosis are transvaginal sonography (TVS) or T-2…

BACKGROUND: Uterine peristalsis sustains sperm transport and can be detected by hysterosalpingoscintigraphy (HSSG). This study is the first to be designed to investigate utero-tubal transport function by HSSG and uterine contractility by in…

A 53-year-old women underwent D & C and diagnostic hysteroscopy for suspected endometrial hyperplasia, when the posterior uterine wall was perforated. An endometrial polyp prolapsed into the abdominal cavity after uterine rupture which was …

The aetiology and pathogenesis of endometriosis, defined as the presence of endometrium-like tissue outside the uterine cavity, is largely unknown. In this paper we present and discuss possibilities to study the putative pathogenic properti…

Endometriosis is one of the most frequent diseases in gynecology. It is a histologically defined nonmalignant disease in which endometrium-like tissue is found outside the uterus (for example, peritoneum, gut, or lung). The pathogenesis of …

OBJECTIVE: Interleukin-6 (IL-6) and soluble Interleukin-6-receptor (sIL-6R) concentrations were investigated in patients with endometriosis and other benign gynecologic diseases. METHODS: During laparoscopy or laparotomy peritoneal fluid an…

The pathogenesis of endometriosis is not known. The currently favoured theory is that viable endometrial cells, shed from the endometrium into the pelvic cavity by retrograde menstruation, reattach and invade other tissues. We used a collag…