Precise Surgical Navigation of Endometriosis via NIR-II Fluorescence Imaging With a Semiconducting Polymeric Probe

Zhihui Huang, Huang Z, Li C, Chao Li, Jinju Lin, Wang Y, Yucheng Wang, Pengfei Zhang, Dan Ding, Huilin Xie, Jianquan Zhang, Ben Zhong Tang
Angewandte Chemie (International ed. in English) · 2026 · vol. 65(42) , pp. e2407891 · doi:10.1002/anie.2407891 · PMID:42634982 · W7204113423
Lab / animal OA: closed public-domain-us
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-08-26 ⓘ

A semiconducting polymer probe, P-BPTI, enables precise NIR-II fluorescence imaging for accurate surgical resection and long-term monitoring of endometriosis lesions in a mouse model.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Endometriosis is a prevalent gynecological disorder characterized by ectopic growth of endometrial-like tissue, often causing chronic pain, infertility, and systemic inflammation. Accurate detection and complete surgical resection remain challenging because lesions are frequently small, multifocal, and visually ambiguous. Fluorescence imaging in the second near-infrared window (NIR‑II, 1000-1700 nm) enables deeper tissue visualization with reduced scattering and autofluorescence, offering improved contrast and spatial resolution. Here, we developed P‑BPTI, a NIR‑II-emissive semiconducting polymer designed to mitigate aggregation-caused quenching (ACQ) and enhance in vivo bioimaging. P‑BPTI nanoparticles exhibit strong NIR‑II fluorescence, excellent photostability, and deep tissue penetration. In a multi-lesion mouse model of endometriosis, P‑BPTI enabled noninvasive lesion visualization and real-time image-guided resection, outperforming both its monomeric counterpart and indocyanine green (ICG). Importantly, repeated administration of P-BPTI NPs at 7-day intervals enabled periodic NIR-II imaging of lesion status for up to 49 days after surgery. Post-operative histological analyses further supported effective lesion removal and reduced pathological activity. Overall, this work demonstrates the potential of P‑BPTI for NIR‑II image-guided surgery and long-term monitoring in endometriosis, with promise for improving lesion localization and therapeutic outcomes.

My notes (saved in your browser only)

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Fluorescent Dyes Fluorescent Dyes Fluorescent Dyes Fluorescent Dyes Fluorescent Dyes Fluorescent Dyes Optical Imaging Optical Imaging Optical Imaging Optical Imaging Polymers Polymers Polymers

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (41)

Source provenance

europepmc
last seen: 2026-10-15T06:08:49.021275+00:00
openalex
last seen: 2026-10-15T06:00:39.803327+00:00
pubmed
last seen: 2026-10-15T06:02:21.945644+00:00
License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine