Risk of developing major depression and anxiety disorders among women with endometriosis: A longitudinal follow-up study

Chen LC, Li-Chi Chen, Ju-Wei Hsu, Hsu JW, Kai-Lin Huang, Huang KL, Ya-Mei Bai, Bai YM, Ya‐Mei Bai, Tung-Ping Su, Tung‐Ping Su, Su TP, Cheng-Ta Li, Cheng‐Ta Li, Albert C. Yang, Wen-Han Chang, Chang WH, Wen‐Han Chang, Tzeng-Ji Chen, Chen TJ, Tzeng‐Ji Chen, Shih-Jen Tsai, Shih‐Jen Tsai, Tsai SJ, Mu‐Hong Chen, Mu-Hong Chen, Chen MH
Journal of affective disorders · 2015 · vol. 190 , pp. 282–285 · doi:10.1016/j.jad.2015.10.030 · PMID:26544610 · W1872595838
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This longitudinal study followed women to investigate the risk of developing major depression and anxiety disorders in those diagnosed with endometriosis.

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Abstract

BACKGROUNDS: Several cross-sectional studies suggested a link between endometriosis and mood disorders. However, the temporal association between endometriosis and mood disorders (depression and anxiety disorders) is still unclear. METHODS: Using the Taiwan National Health Insurance Research Database, 10,439 women with endometriosis and 10,439 (1:1) age-/sex-matched controls between 1998 and 2009 were enrolled, and followed up to the end of 2011. Those who developed depression or anxiety disorders during the follow-up were identified. RESULTS: Women with endometriosis had an increased risk of developing major depression (hazard ratio [HR]: 1.56, 95% confidence interval [CI]:1.24-1.97), any depressive disorder (HR: 1.44, 95% CI: 1.25-1.65), and anxiety disorders (HR: 1.44, 95% CI: 1.22-1.70) in later life compared to those without endometriosis. Stratified by age group, women with endometriosis aged <40 years and those aged ≧40 years were both prone to developing major depression (HR: 1.52, 95% CI: 1.15-1.99; HR: 1.69, 95% CI: 1.09-2.62), any depressive disorder (HR: 1.43, 95% CI: 1.21-1.69; HR: 1.45, 95% CI: 1.13-1.56), and anxiety disorders (HR: 1.39, 95% CI: 1.14-1.71; HR: 1.53, 95% CI: 1.15-2.04). LIMITATION: the incidence of depression and anxiety disorders may be underestimated since only those who sought medical consultation and help would be enrolled in our study. CONCLUSION: Endometriosis was associated with an elevated likelihood of developing depression and anxiety disorders. Further studies may be required to investigate the underlying pathophysiology between endometriosis and both depression and anxiety disorders.

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Condition tags

endometriosis

MeSH descriptors

Anxiety Disorders Endometriosis Major Depressive Disorder Adult Adult Anxiety Disorders Anxiety Disorders Case-Control Studies Case-Control Studies Databases, Factual Databases, Factual Endometriosis Endometriosis Female Female Follow-Up Studies Follow-Up Studies Humans Humans Incidence

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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