Endometrial epithelial metaplasias
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This report details seven categories of endometrial epithelial metaplasia, noting that most affected postmenopausal women had recently used oral estrogen replacement therapy.
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Abstract
Endometrial epithelial metaplasia refers to the replacement of the normal endometrial glandular epithelium by cells that are either not encountered in the normal endometrium or, if present, are usually inconspicuous elements. Because these cells appear unusual or "atypical" and because they may line architecturally complex glands, this benign process is frequently confused with adenocarcinoma. This report concerns the clinical and light-microscopic findings in 89 patients whose endometria demonstrated some form of metaplasia. Most of these metaplastic changes could be placed in one of the following seven categories: 1) morules and squamous metaplasia; 2) syncytial papillary metaplasia; 3) ciliated cell metaplasia ("tubal" metaplasia); 4) eosinophilic metaplasia; 5) mucinous metaplasia; 6) hobnail metaplasia; or 7) clear cell metaplasia. The defining characteristics of each of these groups and their differential diagnoses are discussed. The majority of women whose endometria demonstrated metaplastic transformation were postmenopausal, and most had received some form of oral estrogen replacement therapy within 3 months of the time of curettage or endometrial biopsy.
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Cited by (25)
- Endometritis and Tumor-Like Lesions 2025
- Endometritis and Tumor-Like Lesions 2024
- Classifying Adenomyosis: Progress and Challenges 2021
- Clinical and Pathological Significance of Cellular Atypia in Endometriosis 2021
- Endometrial Calcifications 2020
- Benign Diseases of the Endometrium 2018
- Adenomyosis and Endometrial Cancer: Literature Review 2018
- Mucinous metaplasia of the endometrium: Current concepts 2014
- Papillary Syncytial Metaplasia of Fallopian Tube Endometriosis: A Potential Pitfall in the Diagnosis of Serous Tubal Intraepithelial Carcinoma 2012
- Erkrankungen des Endometriums 2012
- Non-neoplastic endometrium 2012
- International Internet-Based Assessment of Observer Variability for Diagnostically Challenging Endometrial Biopsies 2011
- Altered Endometrial Differentiation (Metaplasia) 2011
- Endometrial metaplasias and reactive changes: a spectrum of altered differentiation 2010
- Colonization of Intestinal Endometriosis by Benign Colonic Mucosa: A Pattern Potentially Misdiagnosed as Invasive Mucinous Carcinoma 2010
- Benign Endometrium 2009
- Polypoid Endometriosis 2004
- Prevalence of endometriosis in malignant epithelial ovary tumours 2003
- Epithelial Abnormalities in Cystic Ovarian Endometriosis 2002
- Ovarian Endometriosis Associated with Ovarian Carcinoma: A Clinicopathological and Immunohistochemical Study 2000
- Effects of tamoxifen on uterus 1994
- Pathology of endometrium treated with tamoxifen. 1994
- Cone biopsy causes cervical endometriosis and tubo‐endometrioid metaplasia 1991
- Mucinous metaplasia to neoplastic lesions in endometrial samples with cytohistologic correlation 1989
- The significance of secretory features and coincident hyperplastic changes in endometrial biopsy specimens 1987
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- last seen: 2026-06-10T16:23:13.998983+00:00
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