Mucinous metaplasia of the endometrium: current concepts

Gulisa Turashvili, Timothy Childs
Gynecologic Oncology · 2014 · vol. 136(2) , pp. 389–393 · doi:10.1016/j.ygyno.2014.12.003 · PMID:25485781 · W2076119228
Review OA: closed CC0 ⤵ 1 in-corpus citation
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

This review discusses current concepts regarding mucinous metaplasia of the endometrium, exploring its potential causes, histological features, and clinical significance.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVES: The objective of this review was to discuss the highly variable terminology describing mucinous metaplasia of the endometrium, histologic features and characteristic findings by special stains and immunohistochemistry, differential diagnostic challenges, current treatment and prognosis. METHODS: A review of the literature was performed on mucinous metaplasia of the endometrium. RESULTS: Mucinous metaplasia is an uncommon type of endometrial epithelial metaplasia, often associated with hyperestrogenic states or hormone replacement therapy. Histologic findings range from simple endocervical-type mucinous epithelium to architecturally complex mucinous proliferations. Mucinous metaplasia often presents a significant diagnostic challenge in endometrial biopsies and should be differentiated from endocervical microglandular hyperplasia, and mucinous or mixed mucinous and endometrioid carcinomas. Simple mucinous metaplasia is believed to have a low risk of associated carcinoma, whereas architecturally complex cases often show invasive malignancy on subsequent biopsy. CONCLUSIONS: Complex mucinous proliferations should be managed with dilatation and curettage and repeat biopsy within 6months, and strong consideration should be given to a hysterectomy in persistent mucinous proliferations.

My notes (saved in your browser only)

MeSH descriptors

Endometrial Neoplasms Endometrium Precancerous Conditions Aged Endometrial Neoplasms Endometrium Female Humans Immunohistochemistry Metaplasia Precancerous Conditions

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (34)

Cited by (1)

Source provenance

openalex
last seen: 2026-05-11T05:54:30.111693+00:00
pubmed
last seen: 2026-10-08T21:14:48.268335+00:00
unpaywall
last seen: 2026-10-14T06:23:58.021457+00:00
License: CC0 · commercial use OK