Naproxen sodium in dysmenorrhea secondary to endometriosis
Non-randomised trial
OA: closed
CC0
⤵ 50 in-corpus citations
AI-generated summary
Naproxen sodium provided complete or substantial pain relief in 83% of women with endometriosis-related dysmenorrhea, significantly more than placebo, with fewer women requiring supplemental analgesics.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
Twenty patients with moderate to very severe painful menstrual periods secondary to endometriosis were treated in a double-blind, four-period, crossover clinical trial with naproxen sodium and placebo. Complete or substantial pain relief was obtained in 83% of the cases of painful menstruation with naproxen sodium and in 41% with placebo (P = .008). Only 5% of the naproxen sodium-treated women needed supplemental analgesics compared with 36% of the placebo-treated women (P = .002). There was a trend towards diminished interference of dysmenorrhea with normal patient activities during naproxen sodium treatment compared with placebo (P = .069). No significant side effects occurred with either treatment. These results indicated that naproxen sodium is efficacious and safe for the treatment of menstrual distress in patients with endometriosis.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood (2-hop)
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]
Cited by (48)
- Safety of current strategies to manage moderate to severe pain in patients with endometriosis 2025
- Clinical Guidance Paper VVOG: Pharmacological treatment of endometriosis-related pain 2025
- Safety and efficacy of pharmacotherapies for pelvic inflammatory disease and endometriosis 2024
- Pathophysiology, diagnosis, and management of endometriosis 2022
- Medical Management of Endometriosis in Adolescents 2020
- Endometriosis Pain Management: a Review 2020
- Manage endometriosis-related pain with hormonal suppression therapies 2019
- Tratamientos farmacológicos de la endometriosis (a excepción de la adenomiosis) 2018
- Current and emerging treatment options for endometriosis 2018
- Current and Emerging Therapeutics for the Management of Endometriosis 2018
- Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis 2017
- Management of endometriosis‐related pelvic pain 2017
- Aberrant PTEN expression in response to progesterone reduces endometriotic stromal cell apoptosis 2016
- Chronic pelvic pain: Pathogenesis and validated assessment 2016
- Naproxen sodium decreases prostaglandins secretion from cultured human endometrial stromal cells modulating metabolizing enzymes mRNA expression 2015
- On-label and off-label drug use in the treatment of endometriosis 2015
- An overview of early drug development for endometriosis 2015
- Current treatment of endometrioma 2015
- Systematic review of endometriosis pain assessment: how to choose a scale? 2014
- Activated AKT pathway promotes establishment of endometriosis 2014
- Endometriosis - An Update 2014
- Endometriosis 2013
- Endometriosis – Pathogenesis, Diagnosis, and Therapeutic Options for Clinical and Ambulatory Care 2013
- An update on the pharmacological management of endometriosis 2013
- New trends for the medical treatment of endometriosis 2012
- Endometriose - Entstehung, Diagnostik, Behandlungsmöglichkeiten und Probleme in Klinik und Praxis 2011
- Endocannabinoid involvement in endometriosis 2010
- Endometriosis 2009
- Minimal endometriosis: a therapeutic dilemma? 2009
- Endometriosis 2008
- Emerging drugs in endometriosis 2006
- ESHRE guideline for the diagnosis and treatment of endometriosis 2005
- A Western primer of Chinese herbal therapy in endometriosis and infertility 2005
- Nonsteroidal antiinflammatory drugs differentially suppress endometriosis in a murine model 2005
- Endometriose endometriose en pijn 2004
- Diagnosis and treatment of endometriosis 2003
- Aetiology and medical treatment of endometriosis 2000
- Endometriosis: an overview of the disease and its treatment 2000
- Today's treatments: how do you choose? 1999
- Today's treatments: medical, surgical and in partnership 1999
- Endometriosis and Pelvic Pain 1998
- Chronic pelvic pain: Oral contraceptives and non-steroidal anti-inflammatory compounds 1997
- The Role of Medical Management in the Treatment of Endometriosis 1995
- Changing concepts of medical treatment of endometriosis 1993
- Nonsteroidal antiinflammatory drugs and reproduction 1993
- Endometriosis and infertility 1990
- Eicosanoids in primary dysmenorrhea, endometriosis and menstrual migraine 1989
- Dysmenorrhö und Leistungssport 1988
Source provenance
- europepmc
- last seen: 2026-10-15T06:08:49.021275+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:44:23.379930+00:00
License: CC0
· commercial use OK