Dienogest Therapy as a Treatment for Catamenial Pneumothorax: Case Report and Review of Hormonal Options

Lalani S, Shifana Lalani, Amanda Black, Meryl C Hodge, Hodge MC, Meryl Hodge, Togas Tulandi, Tulandi T, Innie Chen
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC · 2017 · vol. 39(9) , pp. 764–768 · doi:10.1016/j.jogc.2017.01.014 · PMID:28647447 · W2715113768
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This case report describes the successful use of dienogest to treat catamenial pneumothorax and reviews other hormonal treatment options for this condition.

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Abstract

BACKGROUND: Catamenial pneumothorax is a rare but serious condition for women of reproductive age. We describe a trial of dienogest as hormonal therapy for catamenial pneumothorax and review the literature on hormonal suppressive therapy for this condition. CASE: A 39-year-old female, gravida 0 para 0, presented with recurrent pneumothoraces coinciding with her menses. After surgical therapy, she was started on leuprolide acetate injections for 6 months to reduce recurrence. To reduce long-term side effects of leuprolide acetate, the patient was started on dienogest 4 mg orally once daily instead of leuprolide acetate for hormonal suppression and experienced resolution of recurrent pneumothoraces. CONCLUSION: For women with recurrent catamenial pneumothorax, dienogest may be an effective hormonal treatment option and alternative to long-term GnRH agonist therapy for long-term suppression.

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MeSH descriptors

Hormone Antagonists Leuprolide Nandrolone Pneumothorax Adult Adult Female Female Hormone Antagonists Hormone Antagonists Humans Humans Leuprolide Leuprolide Nandrolone Nandrolone Nandrolone Pneumothorax Pneumothorax

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