Clinical and Pathogenetic Aspects of Thoracic Endometriosis

V. F. Bezhenar, В А Линде, Nadezhda Krylova, Ye.A. Ivanova, Aleksey Pichurov, B.V. Arakelyan, А. Н. Плеханов, A. Yu. Lyogonkaya
In: Effective Pharmacotherapy · 2023 · pp. 12–18 · doi:10.33978/2307-3586-2023-19-37-12-18 · W4389945723
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Abstract

Thoracic endometriosis is a rare pathology that significantly affects the quality of life of women. The pathogenesis of endometriosis continues to be intensively studied. One of the latest achievements in its study is the identification of oxidative stress as an active link in the development of a pathological condition. The nitric oxide molecule is a free radical and, as a result, an important component of oxidative processes. Violation of its metabolism makes a significant contribution to the occurrence of oxidative stress. The NOS3 endothelial synthase gene controls nitric oxide metabolism. We have studied the polymorphism of the NOS3 endothelial synthase gene at points 786 T/C and 894 G/T. The data obtained indicate the active participation of the NOS3 endothelial synthase gene at points 786 T/C and 894 G/T in the pathogenesis of various forms of endometriosis. The difficulties of diagnosing and treating this disease at the present stage are not least due to the fact that the problem of thoracic endometriosis is at the junction of the specialties of obstetrics-gynecology and thoracic surgery, which in other situations practically do not intersect. Our observations make it possible to consider thoracic endometriosis as a pathological process that is not associated with fertility and parity of patients. At the same time, thoracic endometriosis is most likely associated with genital endometriosis, which has a negative impact on fertility. The most common complaints of patients with thoracic endometriosis are pain and discomfort in the chest area associated with menstruation and dry cough. Histological verification of the disease is difficult. A promising method for preventing exacerbations of the disease is the combined prescription of аGnRG and dienogest.

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endometriosisthoracic_endometriosis

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