Endometriosis, macrophages, and adhesions

A F Haney, Haney AF
Progress in clinical and biological research · 1993 · vol. 381 , pp. 19–44 · PMID:8316562 · W2398893403
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Endometriosis is associated with activated macrophages in peritoneal fluid that secrete growth factors and cytokines, potentially altering tissue repair and contributing to adhesion formation.

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Abstract

In the judgement of most experienced clinicians, women with endometriosis are particularly prone to postoperative adhesion formation. Coincidently, a localized sterile PF inflammatory process is present in these women, although not exclusively confined to those with visible endometrial implants. This PF exudate contains numerous growth factors and cytokines, most secreted by the large population of activated macrophages, which have the potential to alter the tissue repair response. To further evaluate this possibility, attention will need to be focused on the nature of the PF immune system, changes in the PF immune response in various gynecologic disease states and the impact of surgery.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Macrophages Pelvic Neoplasms Pelvic Neoplasms Peritoneal Diseases Postoperative Complications Tissue Adhesions Ascitic Fluid Ascitic Fluid Ascitic Fluid Cytokines Cytokines Cytokines Exudates and Transudates Exudates and Transudates Female Female Growth Substances Growth Substances

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (14)

Source provenance

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