The Evolution of Estrogen Receptor Signaling in the Progression of Endometriosis to Endometriosis-Associated Ovarian Cancer

Courtney L Andersen, M.M. Boisen, Matthew J Sikora, Tianzhou Ma, George C. Tseng, George Tseng, Swati Suryawanshi, Anda Vlad, Esther Elishaev, Robert P Edwards, Steffi Oesterreich
Hormones & cancer · 2018 · vol. 9(6) , pp. 399–407 · doi:10.1007/s12672-018-0350-9 · PMID:30302736 · W2895839951
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This study evaluated estrogen signaling gene expression across normal endometrium, endometriosis, and endometriosis-associated ovarian cancer tissue, finding ERα signaling inactivated in EAOC and consistent with endocrine resistance.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study examined how estrogen receptor alpha (ERα) signaling evolves during progression from benign endometriosis to endometriosis-associated ovarian cancer (EAOC) by profiling 236 estrogen-response genes (E2sig) in tissue samples from normal endometrium, benign endometriosis, atypical/concurrent endometriosis, and EAOCs using NanoString analysis, supported by clustering, ANOVA, and gene set enrichment. Across 83 endometriosis/EAOC-related samples and 23 normal endometrium controls, five expression clusters of the differentially expressed estrogen-associated genes were identified, and the EAOC estrogen signaling pattern was not consistent with activated ERα found in pre-clinical models. Instead, gene set enrichment suggested loss of ERα function and a pattern consistent with endocrine resistance in EAOC, and the authors note that menopausal status differences did not explain the clustering or gene-level differences within the normal endometrium dataset. This paper is centrally about endometriosis—specifically, it tracks estrogen signaling changes in progression to endometriosis-associated ovarian cancer (EAOC).

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Carcinoma, Ovarian Epithelial Endometriosis Estrogen Receptor alpha Ovarian Neoplasms Adult Aged Carcinoma, Ovarian Epithelial Carcinoma, Ovarian Epithelial Disease Progression Endometriosis Endometriosis Estrogen Receptor alpha Female Humans Middle Aged Ovarian Neoplasms Ovarian Neoplasms Signal Transduction Signal Transduction Transcriptome

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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