AbstractPurpose: Mechanisms of immune dysregulation associated with advanced tumors are relatively well understood. Much less is known about the role of immune effectors against cancer precursor lesions. Endometrioid and clear-cell ovarian …
AbstractPurpose: Mechanisms of immune dysregulation associated with advanced tumors are relatively well understood. Much less is known about the role of immune effectors against cancer precursor lesions. Endometrioid and clear-cell ovarian …
Supplementary Materials and Methods
Supplementary Materials and Methods
Suppl Fig S1. Venn diagram of DE genes from 3 group comparisons
Suppl Fig S1. Venn diagram of DE genes from 3 group comparisons
Suppl Fig S2. Kras and Pten pathways in relationship to complement gene expression
Suppl Fig S2. Kras and Pten pathways in relationship to complement gene expression
Suppl Fig S3. Antibody-mediated, complement-induced cytotoxicity
Suppl Fig S3. Antibody-mediated, complement-induced cytotoxicity
Suppl Fig S4. Complement and non-target siRNA
Suppl Fig S4. Complement and non-target siRNA
Suppl Table S1. Differentially expressed genes from different group comparisons
Suppl Table S1. Differentially expressed genes from different group comparisons
Suppl Table S2. Top five canonical pathways from different group comparisons, identified via Ingenuity Pathway Analyses
Suppl Table S2. Top five canonical pathways from different group comparisons, identified via Ingenuity Pathway Analyses
Suppl Table S3. Top five networks from different group comparisons, identified via Ingenuity Pathway Analyses
Suppl Table S3. Top five networks from different group comparisons, identified via Ingenuity Pathway Analyses
The immune tumor microenvironment (TME) of epithelial ovarian cancer (EOC) carries both effector and suppressive functions. To define immune correlates of chemotherapy-induced tumor involution, we performed longitudinal evaluation of biomar…
Abstract Objectives: To investigate changes in estrogen receptor–alpha (ERα) signaling during the progression of endometriosis to endometriosis-associated ovarian cancer (EAOC) as a putative driver of malignant transformation. Methods: We p…
Sexually transmitted infection (STI) of the upper reproductive tract can result in inflammation and infertility. A biomarker of STI-induced upper tract inflammation would be significant as many women are asymptomatic and delayed treatment i…
To investigate changes in estrogen receptor alpha (ERα) signaling during progression of endometriosis to endometriosis-associated ovarian cancer (EAOC) as a driver of malignant transformation. We procured tissue samples of normal endometriu…
Abstract Introduction: Endometriosis is a largely benign, chronic inflammatory disease defined by the presence of endometrial-like glands surrounded by stroma. Epidemiologic studies suggest that endometriosis is an independent risk factor f…
PURPOSE: Mechanisms of immune dysregulation associated with advanced tumors are relatively well understood. Much less is known about the role of immune effectors against cancer precursor lesions. Endometrioid and clear-cell ovarian tumors p…