Immune abnormalities in endometriosis compromising fertility in IVF-ET patients
Observational
OA: closed
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⤵ 22 in-corpus citations
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This study found increased incidences of antinuclear and antiphospholipid antibodies in women with endometriosis undergoing IVF, suggesting immune abnormalities may compromise fertility.
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Abstract
OBJECTIVE: To evaluate the incidence of immune abnormalities in patients with endometriosis and primary or secondary infertility.
STUDY DESIGN: This study analyzed the incidence of alloantibodies and autoantibodies in 100 women with endometriosis and 62 patients with unexplained infertility without endometriosis who enrolled in an assisted reproduction program at the Colombian Fertility and Sterility Center from January 1, 1996, to May 30, 1997. The alloimmune status of the women was determined by testing for the presence or absence of antileukocyte antibodies. The autoimmune studies included antinuclear antibodies, antiphospholipid antibodies and lupus anticoagulant antibody.
RESULTS: Negative titers of IgG antipaternal antibodies were identified in 34% of patients with primary infertility and in 34% of women with secondary infertility and a history of pregnancy losses. Positive titers of antinuclear antibodies were found in 27% (27/100) of the group of patients with endometriosis; of them, 30% (15/50) had primary infertility and 24% (12/50), secondary infertility. The average titer was 1/80. Forty-eight percent of the infertile patients (48/100) showed titers of antiphospholipid antibodies for IgG and IgM; 46% of these patients had primary infertility (23/50) and 50% (25/50), secondary infertility. This was significantly higher than in controls (P < .05). Two patients were positive for lupus anticoagulant antibody. In the group of patients with unexplained infertility without endometriosis, the incidence of antinuclear antibodies was 17.7% and of antiphospholipid antibodies, 30.6%.
CONCLUSION: For women with endometriosis, alloimmune and autoimmune evaluation is recommended prior to their undergoing assisted reproduction in order to provide appropriate therapy for each case.
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Cited by (21)
- Concomitant Autoimmunity in Endometriosis Impairs Endometrium-Embryo Crosstalk at the Implantation Site: A Multicenter Case-Control Study 2023
- The Pathological Role of miRNAs in Endometriosis 2023
- Higher IL-1beta level in the follicular liquid of endometriosis compared with non-endometriosis patients 2020
- Effect of the endometriomas on ovarian stimulation and pregnancy rate on assisted reproductive outcomes 2018
- Oocyte quality is decreased in women with minimal or mild endometriosis 2015
- Impact of ovarian endometrioma on ovarian responsiveness and IVF: a systematic review and meta-analysis 2015
- Impact of the endometrioma on ovarian response and pregnancy rate in in vitro fertilization cycles 2014
- The effect of endometriosis on in vitro fertilisation outcome: a systematic review and meta-analysis 2013
- Does ovarian endometrioma affect the number of oocytes retrieved for in vitro fertilization? 2012
- Endometriosis and Autoimmunity 2011
- Deep pelvic endometriosis negatively affects ovarian reserve and the number of oocytes retrieved for in vitro fertilization 2011
- An overview of non-obstructive etiopathogenic mechanisms of endometriosis-related infertility 2010
- Pathogenic mechanisms in endometriosis-associated infertility 2008
- Infertilidad y endometriosis 2007
- Endometriosis associated with defective handling of apoptotic cells in the female genital tract is a major cause of autoimmune disease in women 2006
- Reduced aromatase activity in granulosa cells of women with endometriosis undergoing assisted reproduction techniques 2006
- Stress reactivity and family relationships in the development and treatment of endometriosis 2005
- In vitro fertilization in patients with ovarian endometrioma 2004
- Does Endometriosis Affect the Results of In Vitro Fertilization? 2003
- Ovarian endometriosis: from pathogenesis to surgical treatment 2003
- Effect of endometriosis on in vitro fertilization 2002
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