Effectiveness of the association micronized N-Palmitoylethanolamine (PEA)-transpolydatin in the treatment of chronic pelvic pain related to endometriosis after laparoscopic assessment: a pilot study

Cobellis L, Luigi Cobellis, Maria Antonietta Castaldi, Valentino Giordano, Giordano V, Elisabetta Trabucco, Trabucco E, Pasquale De Franciscis, Marco Torella, Nicola Colacurci, Colacurci N
European journal of obstetrics, gynecology, and reproductive biology · 2011 · vol. 158(1) , pp. 82–86 · doi:10.1016/j.ejogrb.2011.04.011 · PMID:21601979 · W2005376021
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This pilot study assessed the effectiveness of micronized N-palmitoylethanolamine and transpolydatin combination therapy for chronic pelvic pain in endometriosis patients post-laparoscopy.

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Abstract

OBJECTIVE: Aim of our study was to evaluate the effectiveness of the association between N-Palmitoylethanolamine and transpolydatin in the management of chronic pelvic pain related to EMS. STUDY DESIGN: This was a randomized, double-blind, parallel-group, placebo-controlled clinical trial involving 61 subjects, submitted to a first line laparoscopic conservative surgery, who were randomized into 3 groups receiving: group A (n=21) the association N-Palmitoylethanolamine-transpolydatin 400 mg + 40 mg twice a day for 3 months; group B (n=20) the placebo for 3 months; group C (n=20) a single course of Celecoxib 200mg twice a day for 7 consecutive days. Assessments of the severity of pelvic endometriosis (pelvic pain, dysmenorrhoea and dyspareunia) were recorded before and after treatment on a questionnaire and a 10-point VAS. Differences between groups were verified with Kruskal-Wallis ANOVA for non-parametric multiple comparisons. RESULTS: A marked decrease in dysmenorrhoea, dyspareunia and pelvic pain was observed in all groups, and the association between N-Palmitoylethanolamine and transpolydatin resulted to be more effective than placebo (P<.001). Additionally, the treatment with Celecoxib resulted in a decrease in pelvic pain more effective either than the association N-Palmitoylethanolamine and transpolydatin or placebo. CONCLUSION: These preliminary results show that the association between micronized N-Palmitoylethanolamine and transpolydatin is effective in the management of pelvic pain related to endometriosis after laparoscopy. Additionally, this association seems to be safe, shows an optimal control of pain and can be used in patients who are unable to receive other therapies.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Analgesics Endometriosis Glucosides Palmitic Acids Pelvic Pain Stilbenes Adult Adult Amides Amides Analgesics Analgesics Double-Blind Method Double-Blind Method Endocannabinoids Endocannabinoids Endometriosis Endometriosis Endometriosis Ethanolamines

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (33)

Cited by (31)

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