Endometriosis in Association with Müllerian Anomalies

Mustafa Uğur, M Uğur, Cem Turan, C Turan, T Mungan, Tamer Mungan, Esra Kuşçu, E Kuşçu, S Senöz, S. Şenöz, Hilal Tan Ağış, H T Ağiş, Oya Gökmen, O Gökmen
Gynecologic and obstetric investigation · 2010 · vol. 40(4) , pp. 261–264 · doi:10.1159/000292349 · PMID:8586309 · W1985441443
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This study found that endometriosis occurs at similar frequencies in patients with and without müllerian anomalies, though obstructive anomalies were significantly associated with endometriosis.

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Abstract

There have been many theories proposed regarding etiology and pathogenesis of endometriosis. The theories of retrograde menstruation, celomic metaplasia, and müllerian remnants are among these. In order to find out whether a higher prevalence exists in patients with müllerian anomalies and to test these theories, we reviewed the case records of our reproductive endocrinology clinic set up between 1989 and 1994. The study group included patients with müllerian anomalies (n =186) whereas the control group consisted of patients without müllerian anomalies (n = 3,240). The frequency of endometriosis was 37 of 186 (19.8%) in the study group as compared with 619 of 3,240 (19.1%) in the controls (p > 0.05). In 1 patient without functioning endometrium endometriosis was demonstrated. Obstructive anomalies were associated more with endometriosis as compared with nonobstructive anomalies (p 0.05). These results show that endometriosis is not more frequent in patients with müllerian anomalies as a whole, but outflow obstruction is an important contributing factor. Evaluating patients with müllerian anomalies contributes proof in favor of the theories of retrograde menstruation and celomic metaplasia, but against a possible relation of a developmental defect of differentiation or migration of the müllerian duct system during embryogenesis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Mullerian Ducts Adolescent Adult Cell Differentiation Cell Differentiation Cell Movement Cell Movement Endometriosis Endometriosis Female Humans Mullerian Ducts Mullerian Ducts Mullerian Ducts Prevalence

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