Effect of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry on identifing biomarkers of endometriosis

Zhang H, Hong Zhang, Feng J, Jie Feng, Xiaohong Chang, Chang XH, Xiao-Hong Chang, Zhongxing Li, Li ZX, Zhong-xing Li, Xiao-yi Wu, Xiaoyi Wu, Wu XY, Heng Cui, Cui H
Chinese medical journal · 2009 · vol. 122(4) , pp. 373–376 · doi:10.3760/cma.j.issn.0366-6999.2009.04.003 · PMID:19302738 · W2408940320
Diagnostic accuracy OA: gold CC0 ⤵ 21 in-corpus citations
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Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry identified 24 differentially expressed serum proteins in endometriosis patients, achieving high sensitivity and specificity in diagnosing the condition.

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Abstract

BACKGROUND: Endometriosis is a common gynecological disease. This study aimed to screen proteins that were expressed differently in patients with endometriosis versus normal controls using proteomic techniques, surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS). METHODS: Protein chip SELDI-TOF-MS combines the advantages of microarray and mass spectrometry, and can screen latent markers in sera of patients with endometriosis. Serum samples from patients and normal volunteers were analyzed by SELDI-TOF-MS. RESULTS: After comparing the serum protein spectra of 36 patients with 24 normal controls, 24 differently expressed potential biomarkers (P < 0.01) were identified. Using Biomarker Pattern software, we established a tree model of the 60 serum protein spectra. When using the three biomarkers to classify the samples, the sensitivity for diagnosing endometriosis was 91.7%, specificity was 95.8%, and coincidence rate was 93.3%. Then we used serum samples from 12 patients and 8 normal controls to validate the tree model and report the sensitivity for diagnosing endometriosis was 91.7%, specificity was 75%, and coincidence rate was 85%. CONCLUSIONS: SELDI-TOF-MS may be a useful tool in high-risk population screening for endometriosis. The identification and application of the biomarkers need to further study.

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Condition tags

endometriosis

MeSH descriptors

Biomarkers Endometriosis Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Biomarkers Biomarkers Endometriosis Endometriosis Endometriosis Female Female Humans Humans Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (20)

Cited by (21)

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