Hormonal inhibition of endometrium for transcervical endometrial ablation--a prospective study with a 2-year follow-up

Thomas Römer, T Römer, G Schwesinger, Günter Schwesinger
European Journal of Obstetrics & Gynecology and Reproductive Biology · 1997 · vol. 74(2) , pp. 201–203 · doi:10.1016/s0301-2115(97)00103-6 · PMID:9306119 · W2057921948
Non-randomised trial OA: closed CC0 ⤵ 8 in-corpus citations
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This prospective study evaluated the hormonal inhibition of the endometrium for transcervical endometrial ablation, reporting outcomes over a two-year follow-up period.

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Abstract

OBJECTIVE: To determine the best pretreatment of the endometrium prior to roller ball endometrial ablation. STUDY DESIGN: Forty patients with recurrent hypermenorrhea underwent diagnostic hysteroscopy and dilation and curettage. They were then assigned to receive either no pretreatment or pretreatment with danazol, a GnRH-analogue, or a gestagen prior to roller ball endometrial ablation. Endometrial suppression was estimated by the surgeon at the time of the procedure, and endometrial biopsies were obtained. Patients were followed for 24 months. RESULTS: The subjective estimation of the surgeon showed a sufficient pretreatment after danazol or a GnRH-analogue in 90% of the cases. Histological findings correlated with these findings. The highest level of amenorrhoea at 2 years of follow-up was also reached after danazol or GnRH-analogue pretreatment. CONCLUSIONS: Danazol- or GnRH-analogue should be used for pretreatment prior to endometrial ablation using the roller ball technique.

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MeSH descriptors

Electrocoagulation Endometrium Preoperative Care Cohort Studies Contraceptives, Oral, Synthetic Contraceptives, Oral, Synthetic Danazol Danazol Electrocoagulation Electrocoagulation Endometrium Endometrium Estrogen Antagonists Estrogen Antagonists Female Follow-Up Studies Humans Luteolytic Agents Luteolytic Agents Lynestrenol

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