Use of danazol in hysteroscopic surgery for menorrhagia.
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Pretreatment with danazol (800 mg/d for 25 days) before hysteroscopic laser surgery for menorrhagia resulted in excellent outcomes in 97% of 335 patients.
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Abstract
The advent of hysteroscopic laser surgery has provided an alternative to hysterectomy in women with menorrhagia refractory to other forms of treatment. This procedure has been used with considerable success to reproduce the signs and symptoms of Asherman's syndrome when combined with pretreatment using the synthetic steroid Danocrine (danazol). Experience with 335 patients treated with danazol, 800 mg/d, for 25 days before undergoing hysteroscopy with a neodymium:yttrium-aluminum-garnet laser demonstrated that excellent results (amenorrhea or limited spotting) were achieved in 97% of cases. All 46 patients with clotting disorders did well after surgery. The major complications associated with this procedure were fluid overload, profuse bleeding, postoperative urinary tract infections and postoperative hematometra, all of which were controlled successfully. Only one patient had to discontinue danazol treatment because of an adverse reaction.
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Cited by (16)
- Pre-operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding 2013
- Pre-operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding 2012
- Therapeutic options for adenomyosis: a review 2006
- Pre-operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding 2002
- Dysfunctional uterine bleeding: advances in diagnosis and treatment 2001
- A cost effectiveness analysis of goserelin compared with danazol as endometrial thinning agents 2000
- Hormonal inhibition of endometrium for transcervical endometrial ablation-a prospective study with a 2-year follow-up 1997
- Treatment with a gonadotrophin releasing hormone agonist before endometrial resection: a multicentre, randomised controlled trial 1996
- The effects of the gonadotrophin releasing hormone analogue (goserelin) and prostaglandin E<sub>1</sub> (misoprostol) on cervical resistance prior to transcervical resection of the endometrium 1996
- Hysteroscopic Endomyometrial Resection for the Treatment of Menorrhagia in Patients with Major Medical Diseases 1995
- HYSTEROSCOPIC ENDOMETRIAL ABLATION 1995
- Good practice with endometrial ablation 1995
- Evaluation of surgical options in menorrhagia 1994
- Thinning the endometrium prior to ablation: is it worthwhile? 1994
- The potential for the use of GnRH agonists for treatment of dysfunctional uterine bleeding 1992
- Indications for endometrial resection 1992
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- last seen: 2026-06-04T00:00:01.174412+00:00
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