Hormonal inhibition of the endometrium for resectoscopic endometrial ablation
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Histologic studies of patients undergoing endometrial ablation found that leuprolide acetate most effectively suppressed endometrial thickness and vascularity compared to progestins or danazol.
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Abstract
Attempts at inhibiting the thickness and vascularity of the endometrium in preparation for endometrial ablation by using different types of hormones have been reported. To evaluate the effects of two different progestins, danazol, and leuprolide acetate on the endometrium, compared with the features of early proliferative endometrium, histologic studies were done for at least five patients treated with each hormone who then underwent resectoscopic endometrial ablation for treatment of abnormal uterine bleeding. Significant and at times dramatic differences among the treatment groups were found, with progestin-prepared endometrium being the least successful and leuprolide-prepared endometrium the most successful. In addition, the prolonged suppression provided for a period of time after the procedure by depot leuprolide is likely to help inhibit endometrial regeneration and provide even better long-term success of the procedure.
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- The practicability and surgeons’ subjective experiences with vaginal danazol before an operative hysteroscopy 2012
- Nomegestrol acetate versus combined oral contraceptive as rapid endometrial preparation for operative hysteroscopy: a prospective randomised pilot study 2012
- Rapid endometrial preparation for hysteroscopic surgery with oral desogestrel plus vaginal raloxifene: a prospective, randomized pilot study 2007
- Effects of Hormones 2005
- A randomized trial of danazol pretreatment prior to endometrial resection 2002
- Depot Medroxy Progesterone Acetate: A Poor Preparatory Agent for Endometrial Resection 2001
- Is endometrial pre-treatment of value in improving the outcome of transcervical resection of the endometrium? 2000
- Medium‐term follow‐up of women with menorrhagia treated by rollerball endometrial ablation 2000
- Altered uterine artery blood flow impedance after danazol therapy: possible mode of action in dysfunctional uterine bleeding 1999
- Is routine preoperative preparation necessary for hysteroscopic endometrial resection? 1999
- Efficacy of preoperative medical treatment in facilitating hysteroscopic endometrial resection, myomectomy and metroplasty: literature review 1998
- Endometrial Na+, K+-ATPase pump function and vasopressin levels during hysteroscopic surgery in patients pretreated with GnRH agonist 1998
- Biochemical hemodynamic and hematological changes during transcervical resection of the endometrium using 1.5% glycine as the irrigating solution 1998
- Endometrial resection and late reoperation in the treatment of menorrhagia 1997
- Hormonal inhibition of endometrium for transcervical endometrial ablation-a prospective study with a 2-year follow-up 1997
- Administration of medroxyprogesterone acetate after endomyometrial resection 1997
- The degree of fluid absorption during hysteroscopic surgery in patients pretreated with goserelin 1996
- Endometrial Ablation: Complications and Outcome 1996
- Treatment with a gonadotrophin releasing hormone agonist before endometrial resection: a multicentre, randomised controlled trial 1996
- Endometrial Destruction by Hyperthermia — a Possible Treatment of Menorrhagia 1996
- A mathematical model for light dosimetry in photodynamic destruction of human endometrium 1996
- Uterus and endometrium: Microvascular density in conditions of endometrial atrophy 1996
- Endometrial Resection for the Treatment of Menorrhagia 1996
- Depot goserelin and danazol pre-treatment before rollerball endometrial ablation for menorrhagia 1996
- A comparison of goserelin and danazol as endometrial thinning agents prior to endometrial laser ablation 1996
- Medium-term follow-up of women with menorrhagia treated by rollerball endometrial ablation 1996
- Hysteroscopic endomyometrial resection for the treatment of menorrhagia — follow-up of 86 cases 1995
- Effects of Hormones 1995
- Endometrial Electrosurgical Resection by Hysteroscopy in 32 Menorrhagic Patients: Endometrial Preparation with a GnRH Agonist May Have Some Effect on Results 1995
- HYSTEROSCOPIC ENDOMETRIAL ABLATION 1995
- 9 Audit of currently available endometrial ablative techniques 1995
- 4 Endometrial resection 1995
- Hysteroscopic Endomyometrial Resection for the Treatment of Menorrhagia in Patients with Major Medical Diseases 1995
- Good practice with endometrial ablation 1995
- Benign Diseases of the Endometrium 1994
- The histopathology of transcervical resection of the endometrium: an analysis of 200 cases 1993
- Management of uncontrolled menorrhagia with the resectoscope 1992
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