Surgery versus conservative management of endometriomas in subfertile women. A systematic review

Jacob Brink Laursen, Jeppe Bennekou Schroll, Jeppe B Schroll, Kirsten Tryde Macklon, Martin Rudnicki
Acta obstetricia et gynecologica Scandinavica · 2017 · vol. 96(6) , pp. 727–735 · doi:10.1111/aogs.13154 · PMID:28421599 · W2606947754
Systematic review / meta-analysis OA: bronze CC0 ⤵ 41 in-corpus citations
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This systematic review found very low quality evidence suggesting no difference in live birth odds between surgically removing endometriomas or managing them conservatively before IVF/ICSI.

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Abstract

INTRODUCTION: Endometriomas are present in up to 44% of all women with endometriosis and have a detrimental effect on fertility. However, it is controversial whether endometriomas should be surgically removed before assisted reproduction technology. Our purpose was to evaluate whether surgical stripping of endometriomas in subfertile women improves the chance of a live birth. Secondary outcomes were impact on ovarian reserve and pain. MATERIAL AND METHODS: We conducted a systematic review and meta-analysis with results reported in accordance to the PRISMA guidelines. A summary of findings table was developed using GRADE. We searched Medline and Embase. Two reviewers performed the screening. RESULTS: Of 686 manuscripts, we included one randomized controlled trial and nine retrospective cohort studies, mostly of low quality. The odds ratio for live birth after surgery [compared with conservative management before in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI)] was 0.87 (95% CI 0.64-1.18, six studies, I2  = 3%; ⨁◯◯◯, VERY LOW quality). The mean difference of antral follicle count was -2.09 (95% CI -4.84 to 0.67, four studies). No difference was observed regarding antral follicle count between the two groups (MD -2.09, 95% CI -4.84 to 0.67, four studies, ⨁◯◯◯, VERY LOW quality). Pain outcome was not reported in the included studies. CONCLUSION: The very low quality evidence suggests no difference in odds ratio of live birth between women who underwent surgery for endometriomas before IVF/ICSI compared with conservative management. Further high quality studies are needed, but due to a lack of convincing evidence favoring surgery, we recommend considering conservative treatment if the only indication is subfertility.

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Condition tags

endometriosis

MeSH descriptors

Conservative Treatment Endometriosis Infertility, Female Reproductive Techniques, Assisted Reproductive Techniques, Assisted Conservative Treatment Conservative Treatment Endometriosis Endometriosis Endometriosis Endometriosis Female Female Fertilization in Vitro Fertilization in Vitro Fertilization in Vitro Humans Humans Infertility, Female Infertility, Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (37)

Cited by (42)

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