Histomorphological Aspects of the Ovarian Cortex Regarding Ovarian Reserve and Local Pelvic Inflammation

Michio Kitajima, Naoko Murakami, Ken Taniguchi, Yuriko Kitajima, Ozora Tsukamoto, Kiyonori Miura, Hideaki Masuzaki
In: Journal of Mammalian Ova Research · 2018 · vol. 35(1) , pp. 21–26 · doi:10.1274/jmor.35.21 · W2801413895
article OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated how pelvic inflammation, particularly from endometriosis, alters ovarian cortex histology, potentially accelerating primordial follicle loss and diminishing ovarian reserve.

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Abstract

The ovaries of women of reproductive age may show specific histological structures that may relate to the maintenance of primordial follicles and the regulation of early follicular development, which are keys to understanding the dynamics of ovarian reserve. The pelvic environment of women is frequently exposed to physiological or pathological inflammatory stimuli. Endometriosis is a disorder that should be viewed as a chronic inflammatory disease manifested by pelvic pain and infertility. Inflammation surrounding the normal ovarian cortex may alter the histological structure which possesses primordial and early growing follicles. Fibrotic changes in histological niches in the nest of primordial follicles may provoke activation of dormant follicles and concomitant atresia. Along with decline in AMH, which is produced by early growing follicles, fibrotic changes may accelerate the demise of primordial follicles which has been described as "burn-out by inflammation". As a result, women with endometriosis may suffer from diminished ovarian reserve, a possible cause of endometriosis-related infertility.

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endometriosisinfertility

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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