Identification of epidermal growth factor, transforming growth factor-alpha, and epidermal growth factor receptor in surgically induced endometriosis in rats
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⤵ 18 in-corpus citations
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This study found that epidermal growth factor, transforming growth factor-alpha, and their receptor are present in surgically induced endometriosis in rats, suggesting a potential role in tissue maintenance.
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Abstract
The present immunohistochemical studies used polyclonal antibodies specific to epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha), and monoclonal antibodies to the extracellular binding domain of EGF receptor to elucidate their presence and cellular distribution in surgically induced endometriosis in the rat. Uterine segments were implanted in the mesenteric region adjacent to a blood vessel for a period of 4-6 weeks. During operative reexploration, the implanted tissues were intact, morphologically similar to the controls, and consisted of a cyst containing clear fluid and associated adhesion formation. All the uterine cell types immunostained with antibody to EGF. The highest immunostaining intensity was associated with inflammatory cells infiltrated among endometrial stromal cells, followed by luminal and glandular epithelial and stromal cells. The cysts consisted of an inner simple columnar epithelium, surrounded by several layers of smooth muscle and connective tissue. The cyst epithelial layer immunostained weakly, while the supporting wall stained moderately. The inflammatory cells found within the cyst cavity immunostained very intensely, comparable to those in the endometrium. The patterns of immunostaining for TGF-alpha and EGF receptor were similar to that observed for EGF. Myometrial smooth-muscle cells and endothelial and smooth-muscle cells of arterioles were also immunostained for EGF, TGF-alpha, and EGF receptor, but with lower intensity than that of the endometrium. These observations suggest that, like normal uterine tissue, endometrial implants produce EGF and TGF-alpha locally and contain receptors for EGF. These results imply a possible paracrine or autocrine role for growth factors in the establishment and/or maintenance of endometriotic tissue.
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Cited by (18)
- Immunomodulatory effects of vitamin D3 on gene expression of MDGF, EGF and PDGFB in endometriosis 2020
- Immunology of endometriosis 2018
- Endometriosis - An Update 2014
- A novel role of the Sp/KLF transcription factor KLF11 in arresting progression of endometriosis 2013
- Alternative activation of macrophages in rhesus macaques (Macaca mulatta) with endometriosis 2012
- Expression and role of peptides, proteins and growth factors in the pathogenesis of endometriosis 2009
- Untersuchungen zur Expression und endokrinen Regulation der epidermal growth factor receptor Familie in endometriotischen Läsionen 2007
- Endometriosis and inflammation in infertility 2004
- Serum concentrations of growth factors in women with and without endometriosis: the action of anti-endometriosis medicines 2003
- Macrophages, oxidation, and endometriosis 2002
- Paracrine regulation of matrix metalloproteinase expression in endometriosis 2002
- Endometriosis, Endometrioma, and the Problem of Adhesions 2000
- Hormone replacement therapy following hysterectomy for endometriosis 1998
- Women of reproductive age with endometriosis are not osteopenic 1998
- Morphologic characteristics of endometriosis in the mouse model: application to toxicology 1997
- Peritoneal growth factors and endometriosis 1996
- De novo formation of adhesions in endometriosis: the role of iron and free radical reactions 1995
- The effect of growth factors on the proliferation of human endometrial stromal cells in culture 1993
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organisms 2
rattus sp.
zitter rats
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- europepmc
- last seen: 2026-10-16T06:09:50.462052+00:00
- openalex
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- pubmed
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- scilite
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