Concomitant treatment of severe uterine adenomyosis in a premenopausal woman with an aromatase inhibitor and a gonadotropin-releasing hormone agonist

Fuminori Kimura, Kimura F, Kentaro Takahashi, Takahashi K, Koichi Takebayashi, Takebayashi K, Fujiwara M, Mutsuko Fujiwara, Nobuyuki Kita, Kita N, Noda Y, Yoichi Noda, Nobuhiro Harada, Harada N
Fertility and sterility · 2007 · vol. 87(6) , pp. 1468.e9–1468.e12 · doi:10.1016/j.fertnstert.2006.09.010 · PMID:17222833 · W2042004738
Case report OA: closed CC0 ⤵ 24 in-corpus citations
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This case report describes successful treatment of severe uterine adenomyosis in a premenopausal woman using a combination of an aromatase inhibitor and a gonadotropin-releasing hormone agonist.

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Abstract

OBJECTIVE: To assess the effect of aromatase inhibitors with GnRH agonist for a severe symptomatic adenomyosis that is refractory to GnRH agonist and danazol with GnRH agonist. DESIGN: Case report. SETTING: Clinical practice in university hospital. PATIENT(S): A 34-year-old woman with a complaint of severe dysmenorrheal, symptomatic anemia, and a desire to retain fertility. INTERVENTION(S): Aromatase inhibitor anastrozole given orally (1.0 mg or 2.0 mg daily) for 16 weeks and GnRH agonist given monthly (injected SC, 1.8 mg) for 4 months. MAIN OUTCOME MEASURE(S): Measurements of uterine volume and levels of serum E(2), estrone, A, dehydroepiandrosterone sulfate, LH, FSH, and CA125. RESULT(S): Uterine volume was reduced. The reduction rate of uterine volume estimated by magnetic resonance imaging and ultrasonography was 60% after 8 weeks of treatment. CONCLUSION(S): Aromatase inhibitor with GnRH agonist therapy was useful for the management of a severely adenomyotic woman whose desire was for conservative treatment.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Aromatase Inhibitors Buserelin Endometriosis Gonadotropin-Releasing Hormone Uterine Diseases Adult Adult Aromatase Inhibitors Aromatase Inhibitors Buserelin Buserelin Endometriosis Endometriosis Endometriosis Female Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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Cited by (27)

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