Endometrial nerve fibres in endometriosis

Natsuko Tokushige, Moamar Al‐Jefout, Hilmy Salih, Ian S. Fraser
2007 · vol. 5(3) , pp. 81–88 · W2183469344
article OA: green CC0 ⤵ 5 in-corpus citations
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This review describes the presence of unmyelinated sensory nerve fibers, particularly C nerve fibers, and increased nerve growth factor expression in endometriosis lesions and endometrium.

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Abstract

Endometriosis is a common gynaecological disease that can cause severe\npelvic pain such as dysmenorrhoea and dyspareunia, however the\nmechanisms by which pain is generated are not well understood. Nerve\nfibres in endometriotic plaques have been reported by several authors.\nWe have recently demonstrated the presence of unmyelinated sensory\nnerve fibres (using the pan-neuronal marker PGP9.5) in the functional\nlayer of endometrium in women with endometriosis and a significantly\nincreased nerve fibre density in endometrium and myometrium in women\nwith endometriosis compared with women without endometriosis. Sensory C\nnerve fibres were only detected in the functional layer of endometrium\nof women with endometriosis and never in women without endometriosis.\nThis finding is so consistent that it may become an effective means of\nmaking the diagnosis of endometriosis. Nerve fibres expressing a range\nof neuronal markers and an over-expression of nerve growth factor (NGF)\nand nerve growth factor receptor (NGFRp75) were also demonstrated in\nperitoneal endometrial plaques in women with endometriosis. Effects of\ncurrently available medications for endometriosis on nerve fibres in\neutopic endometrium in hormonally treated women have been also studied.\nThis review will describe nerve fibres in eutopic endometrium and\nectopic endometriotic plaques in women with endometriosis.

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endometriosisdysmenorrheadyspareunia

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