Peritoneal fluid proteome in women with different ASRM stages of endometriosis

Simone Ferrero, Gillott DJ, David J. Gillott, Valentino Remorgida, Paola Anserini, Nicola Ragni, Ragni N, Jurgis G Grudzinskas, J. G. Grudzinskas, Grudzinskas JG
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2008 · vol. 24(8) , pp. 433–441 · doi:10.1080/09513590802173824 · PMID:18850380 · W2088027082
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This study found distinct protein expression patterns in peritoneal fluid between women with early-stage (I-II) and advanced-stage (III-IV) endometriosis, with molecules involved in inflammation and immune response being differentially abundant.

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Abstract

OBJECTIVE: Endometriosis has a wide range of severity but molecular factors associated with variable extension of the disease have not been widely investigated. The present study compares the peritoneal fluid (PF) proteome of 109 women with endometriosis and different disease stage as defined by the American Society for Reproductive Medicine (ASRM). METHODS: PF samples were subjected to two-dimensional gel electrophoresis; protein spots of interest were identified by liquid chromatography tandem mass spectrometry. RESULTS: Over 470 protein spots were analyzed. One isoform of haptoglobin alpha chain, alpha-1b-glycoprotein and one unknown protein had higher expression in PF of women with ASRM stage I-II endometriosis. Four isoforms of alpha1-antitrypsin, three isoforms of alpha-1b-glycoprotein, one isoform of S100-A8 and serotransferrin had higher expression in PF of women with ASRM stage III-IV disease. CONCLUSIONS: Several protein isoforms have different expression in PF of women with ASRM stage I-II endometriosis than in those with ASRM stage III-IV disease; most of these molecules are involved in inflammation and immune response.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Peritoneal Diseases Proteome Adult Adult Ascitic Fluid Ascitic Fluid Ascitic Fluid Disease Progression Disease Progression Electrophoresis, Gel, Two-Dimensional Electrophoresis, Gel, Two-Dimensional Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (39)

Cited by (23)

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