Models of Endometriosis: Animal Models II – Non‐Human Primates

Asgerally T Fazleabas
In: Endometriosis · 2011 · pp. 285–291 · doi:10.1002/9781444398519.ch27 · W1546849876
other OA: closed CC0 ⤵ 4 in-corpus citations
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Non-human primates spontaneously develop endometriosis and can be induced to model retrograde menstruation, enabling molecular and cellular studies of lesion development and impact on fertility.

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Abstract

Endometriosis is a gynecological disease that was described over 100 years ago. Due to its enigmatic nature and extended period of diagnosis, the basic etiology and pathophysiology of the disease remain unresolved. The non-human primate is an ideal model in which to study the disease since not only do these animals get the disease spontaneously, as do women, but the ability to induce the disease by mimicking retrograde menstruation allows us to understand the mechanisms by which lesions develop and progress and the impact of the disease on the function of the eutopic endometrium. This chapter summarizes the extensive molecular and cellular studies that have been conducted using the baboon model of induced disease and provides insight into the early events that may contribute to lesion development, as well as the changes in the eutopic endometrium as a result of endometriosis which could have significant implications on fertility.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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