Economic burden of endometriosis

Systematic review / meta-analysis OA: bronze CC0 ⤵ 232 in-corpus citations
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This paper analyzes the economic burden associated with endometriosis, including direct medical costs, indirect costs of lost productivity, and intangible costs of reduced quality of life.

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Abstract

OBJECTIVE: To comprehensively review and evaluate the direct costs of endometriosis. DESIGN AND SETTING: We systematically reviewed studies published since 1990, and conducted an analysis of publicly available national databases (Healthcare Cost and Utilization Project and National Ambulatory Medical Care Survey/National Hospital Ambulatory Medical Care Survey) in the United States. We assessed: [1] the overall economic impact of endometriosis; [2] the direct costs associated with specific treatments; and [3] the indirect costs of endometriosis associated with reduced work productivity. RESULTS: Of 13 published studies meeting inclusion criteria, 11 (85%) addressed direct costs, a few studies addressed outpatient costs or indirect costs, and no study quantified the economic impact among adolescents. Direct endometriosis-related costs were considerable and appeared driven by hospitalizations. Our database analysis found: [1] as endometriosis-related hospital length of stay steadily declined from 1993 to 2002, per-patient cost increased 61%; [2] adolescents (aged 10-17 years) had endometriosis-related hospitalizations; [3] approximately 50% of >600,000 endometriosis-related ambulatory patient visits involved specialist care; and [4] females 23 years old or younger constituted >20% of endometriosis-related outpatient visits. CONCLUSIONS: Health economic information for endometriosis is scarce, limiting our understanding of its overall economic impact. Nevertheless, the literature and other available data suggest that endometriosis places a considerable burden on patients and society.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Cost of Illness Cost of Illness Employment Endometriosis Endometriosis Health Care Costs Pelvic Pain Pelvic Pain Adolescent Adolescent Adult Adult Aged Aged Aged, 80 and over Aged, 80 and over Comorbidity Comorbidity Employment Employment

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (63)

Cited by (50)

Source provenance

europepmc
last seen: 2026-10-17T06:09:56.316927+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:04:05.892929+00:00
License: CC0 · commercial use OK