Endometrial expression and in vitro modulation of the iron transporter divalent metal transporter-1: implications for endometriosis

Carlos Patricio Alvarado-Díaz, Alvarado-Díaz CP, Marco T. Núñez, Marco Tulio Núñez, Núñez MT, Luigi Devoto, Devoto L, González-Ramos R, Reinaldo González-Ramos
Fertility and sterility · 2016 · vol. 106(2) , pp. 393–401 · doi:10.1016/j.fertnstert.2016.04.002 · PMID:27117373 · W2338730519
Observational OA: closed CC0 ⤵ 13 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This study investigated endometrial expression of the iron transporter DMT1 and its modulation in vitro, exploring implications for endometriosis pathology.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To evaluate divalent metal transporter-1 (DMT1) expression in healthy women's and endometriosis patients' endometrium and to analyze DMT1 and ferritin light chain (Fn-L) expression modulation by iron overload and IL-1β in endometrial stromal cells (ESCs). DESIGN: Observational and experimental study. SETTING: University hospital research laboratory. PATIENT(S): Thirty-one healthy women and 24 endometriosis patients. INTERVENTION(S): Menstrual, proliferative, and secretory endometrial biopsies. Isolated ESCs from seven endometrial biopsies incubated with IL-1β or FeSO4 overload for 24 hours. MAIN OUTCOME MEASURE(S): Divalent metal transporter-1 endometrial protein expression assessed by immunohistochemistry and Western blot. Divalent metal transporter-1 and Fn-L proteins expression in stimulated ESCs evaluated by Western blot. RESULT(S): Divalent metal transporter-1 is expressed throughout the menstrual cycle in human endometrium. Four endometrial DMT1 variants were identified accordingly to their molecular weight: DMT-80, -65, -55, and -50. Endometrial expression of DMT-80 and -55 is higher in endometriosis patients than in healthy women. In ESCs, iron overload induces an overexpression of DMT-80, DMT-50, and Fn-L, whereas IL-1β increases DMT-80 and -50 expressions and decreases Fn-L expression. CONCLUSION(S): Divalent metal transporter-1 overexpression in endometriosis patients' endometrium can increase iron influx to endometrial cells, inducing oxidative stress-mediated proinflammatory signaling. In turn, endometriosis-related conditions, as iron overload and inflammation (IL-1β), enhance endometriosis patients endometrial DMT1 expression, creating a vicious circle on DMT-1-modulated pathways.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Cation Transport Proteins Endometriosis Endometrium Stromal Cells Apoferritins Apoferritins Apoferritins Biopsy Biopsy Case-Control Studies Case-Control Studies Cation Transport Proteins Cation Transport Proteins Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (80)

Cited by (13)

Source provenance

europepmc
last seen: 2026-10-16T06:09:50.462052+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:17:40.612859+00:00
unpaywall
last seen: 2026-09-17T06:32:46.214484+00:00
License: CC0 · commercial use OK