Endometrial flushing αVβ3 integrin, glycodelin and PGF2α levels for evaluating endometrial receptivity in women with polycystic ovary syndrome, myoma uteri and endometrioma

Mustafa Demir, Demir M, Onur İnce, Bulent Ozkan, Bülent Özkan, Ozkan B, Kelekci S, Sefa Kelekci, Sefa Kelekçi, Recep Sütçü, Recep Sutcu, Sutcu R, Yilmaz B, Bulent Yilmaz, Bülent Yılmaz
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2017 · vol. 33(9) , pp. 716–720 · doi:10.1080/09513590.2017.1318276 · PMID:28454508 · W2608307610
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Endometrial flushing revealed higher α<sub>V</sub>β<sub>3</sub> integrin in endometrioma patients, higher glycodelin in endometrioma patients, and higher PGF2α in PCOS patients compared to controls and other groups.

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Abstract

The aim of this cross-sectional study is to compare endometrial flushing fluid levels of αVβ3 integrin, glycodelin and PGF2α during the midluteal phase of the menstrual cycle of women with polycystic ovary syndrome (PCOS, n = 20), myoma uteri (n = 20) and endometrioma (n = 19) with the healthy controls (n = 20). After collecting samples at the midluteal phase of ovulatory volunteers and storing them at -80 °C, αVβ3 integrin, glycodelin and PGF2α levels were analyzed using ELISA. The mean ages of the groups were 28.90 ± 5.45, 37.25 ± 2.73, 32.84 ± 6.62 and 32.15 ± 5.18 in PCOS, myoma uteri, endometrioma and control groups, respectively. The αVβ3 integrin level (ng/ml) was statistically significantly higher in endometrioma group (9.70 ± 1.72, p < 0.05) as compared to myoma uteri and control groups. Similarly, glycodelin level (ng/ml) was significantly higher in endometrioma group (341.04 ± 93.32) than PCOS (p < 0.01), myoma uteri (p < 0.001) and healthy subjects (p < 0.001). Moreover, PGF2α level (350.04 ± 464.50 ng/ml) was significantly higher in PCOS group relative to myoma uteri (p < 0.001), endometrioma (p < 0.05) and control (p < 0.05) groups. In conclusion, αVβ3 integrin level was significantly higher in endometrioma subjects than those with myoma uteri and control groups; glycodelin level was significantly higher in endometrioma group than other three groups, and lastly, PCOS patients had significantly higher PGF2α levels than those patients with myoma uteri, endometrioma and controls.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Dinoprost Endometriosis Endometrium Glycodelin Integrin alphaVbeta3 Leiomyoma Polycystic Ovary Syndrome Uterine Neoplasms Adult Adult Body Fluids Body Fluids Body Fluids Cross-Sectional Studies Cross-Sectional Studies Dinoprost Dinoprost Endometriosis Endometriosis Endometrium

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