Combined effect of dydrogesterone and letrozole on humoral immune function, sex hormone levels and serology-related indices in patients with endometriosis

Dacheng Qu, Xiaoping Huang, Yamei Yang
In: Tropical Journal of Pharmaceutical Research · 2019 · vol. 18(2) , pp. 415 · doi:10.4314/tjpr.v18i2.28 · W2921642892
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In 98 endometriosis patients, combined dydrogesterone and letrozole treatment yielded higher clinical effectiveness than dydrogesterone alone, significantly lowering estradiol levels while improving humoral immunity.

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This study evaluated the combined effects of dydrogesterone and letrozole on humoral immunity, sex hormones, and serological indices in 98 patients with endometriosis. Participants were randomized to receive either dydrogesterone alone or a combination of dydrogesterone and letrozole for one month, after which clinical effectiveness and biological markers were assessed. The combination therapy resulted in significantly higher total effectiveness rates compared to monotherapy, along with lower estradiol levels and improved humoral immune function indicators such as IgM, IgG, and C3. This paper is centrally about endometriosis — specifically the pharmacological management of the condition using a dual-hormone regimen.

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Abstract

Purpose: To investigate the combined effect of dydrogesterone and letrozole on humoral immunity, and levels of sex hormones and serology-related indices in patients with endometriosis.Methods: Patients with endometriosis (98 cases) were randomly assigned to two groups of 49 patients each: control group and study group. The control group received dydrogesterone (10 mg/kg) orally from the fifth day to the twenty-fifth day of the patient's menstrual cycle, twice daily; while the study group, in addition to dydrogesterone (10 mg/kg), received letrozole (2.5 mg/kg). Treatment in both groups lasted one month, and changes in the levels of humoral immunity, sex hormones and serology-related indices were evaluated before and after treatment. Clinical effectiveness and adverse reactions in both groups were also assessed.Results: After treatment, total effectiveness was markedly higher in the study group (91.84 %) than in control group (77.55 %, p < 0.05). Post-treatment, humoral immunity (IgM, IgG and C3) levels were significantly higher in the study group than in control group (p < 0.05) while estradiol (E2) level in both groups were significantly reduced; however, E2 level was markedly lower in the study group than in control group (p < 0.05).Conclusion: These results suggest that the combination of dydrogesterone with letrozole alleviates clinical symptoms of endometriosis, improves humoral immune function, and maintains sex hormone levels.Keywords: Endometriosis, Dydrogesterone, Letrozole, Humoral immunity, Sex hormones, Serologicalrelated indices
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Abstract

Purpose: To investigate the combined effect of dydrogesterone and letrozole on humoral immunity, and levels of sex hormones and serology-related indices in patients with endometriosis.

Methods

Patients with endometriosis (98 cases) were randomly assigned to two groups of 49 patients each: control group and study group. The control group received dydrogesterone (10 mg/kg) orally from the fifth day to the twenty-fifth day of the patient's menstrual cycle, twice daily; while the study group, in addition to dydrogesterone (10 mg/kg), received letrozole (2.5 mg/kg). Treatment in both groups lasted one month, and changes in the levels of humoral immunity, sex hormones and serology-related indices were evaluated before and after treatment. Clinical effectiveness and adverse reactions in both groups were also assessed.

Results

After treatment, total effectiveness was markedly higher in the study group (91.84 %) than in control group (77.55 %, p < 0.05). Post-treatment, humoral immunity (IgM, IgG and C3) levels were significantly higher in the study group than in control group (p < 0.05) while estradiol (E2) level in both groups were significantly reduced; however, E2 level was markedly lower in the study group than in control group (p < 0.05).

Conclusion

These results suggest that the combination of dydrogesterone with letrozole alleviates clinical symptoms of endometriosis, improves humoral immune function, and maintains sex hormone levels.

Keywords

Endometriosis, Dydrogesterone, Letrozole, Humoral immunity, Sex hormones, Serologicalrelated indices

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