Combined effect of dydrogesterone and letrozole on humoral immune function, sex hormone levels and serology-related indices in patients with endometriosis
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Abstract
Purpose: To investigate the combined effect of dydrogesterone and letrozole on humoral immunity, and levels of sex hormones and serology-related indices in patients with endometriosis.Methods: Patients with endometriosis (98 cases) were randomly assigned to two groups of 49 patients each: control group and study group. The control group received dydrogesterone (10 mg/kg) orally from the fifth day to the twenty-fifth day of the patient's menstrual cycle, twice daily; while the study group, in addition to dydrogesterone (10 mg/kg), received letrozole (2.5 mg/kg). Treatment in both groups lasted one month, and changes in the levels of humoral immunity, sex hormones and serology-related indices were evaluated before and after treatment. Clinical effectiveness and adverse reactions in both groups were also assessed.Results: After treatment, total effectiveness was markedly higher in the study group (91.84 %) than in control group (77.55 %, p < 0.05). Post-treatment, humoral immunity (IgM, IgG and C3) levels were significantly higher in the study group than in control group (p < 0.05) while estradiol (E2) level in both groups were significantly reduced; however, E2 level was markedly lower in the study group than in control group (p < 0.05).Conclusion: These results suggest that the combination of dydrogesterone with letrozole alleviates clinical symptoms of endometriosis, improves humoral immune function, and maintains sex hormone levels.Keywords: Endometriosis, Dydrogesterone, Letrozole, Humoral immunity, Sex hormones, Serologicalrelated indices
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Abstract
Purpose: To investigate the combined effect of dydrogesterone and letrozole on humoral immunity, and levels of sex hormones and serology-related indices in patients with endometriosis.
Methods
Patients with endometriosis (98 cases) were randomly assigned to two groups of 49 patients each: control group and study group. The control group received dydrogesterone (10 mg/kg) orally from the fifth day to the twenty-fifth day of the patient's menstrual cycle, twice daily; while the study group, in addition to dydrogesterone (10 mg/kg), received letrozole (2.5 mg/kg). Treatment in both groups lasted one month, and changes in the levels of humoral immunity, sex hormones and serology-related indices were evaluated before and after treatment. Clinical effectiveness and adverse reactions in both groups were also assessed.
Results
After treatment, total effectiveness was markedly higher in the study group (91.84 %) than in control group (77.55 %, p < 0.05). Post-treatment, humoral immunity (IgM, IgG and C3) levels were significantly higher in the study group than in control group (p < 0.05) while estradiol (E2) level in both groups were significantly reduced; however, E2 level was markedly lower in the study group than in control group (p < 0.05).
Conclusion
These results suggest that the combination of dydrogesterone with letrozole alleviates clinical symptoms of endometriosis, improves humoral immune function, and maintains sex hormone levels.
Keywords
Endometriosis, Dydrogesterone, Letrozole, Humoral immunity, Sex hormones, Serologicalrelated indices
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Cites (2)
- The short form endometriosis health profile (EHP-5): translation and validation study of the Iranian version 2011
- Endometrial flushing α<sub>V</sub>β<sub>3</sub> integrin, glycodelin and PGF2α levels for evaluating endometrial receptivity in women with polycystic ovary syndrome, myoma uteri and endometrioma 2017
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References (6)
- Endometrial flushing α<sub>V</sub>β<sub>3</sub> integrin, glycodelin and PGF2α levels for evaluating endometrial receptivity in women with polycystic ovary syndrome, myoma uteri and endometrioma via openalex
- The short form endometriosis health profile (EHP-5): translation and validation study of the Iranian version via openalex
- W2130192578 via openalex
- W2775908010 via openalex
- W2973455181 via openalex
- W4285719527 via openalex
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- last seen: 2026-06-10T17:14:06.276822+00:00
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