Dopamine agonists as genital endometriosis target therapy

Maria I. Yarmolinskaya, Е. В. Суслова, Natalia N. Tkachenko, А. С. Молотков, Igor Yu. Kogan
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2020 · vol. 36(sup1) , pp. 7–11 · doi:10.1080/09513590.2020.1816720 · PMID:33305662 · W3111756901
Non-randomised trial OA: hybrid CC0 ⤵ 8 in-corpus citations
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This study found that elevated prolactin levels are involved in genital endometriosis, and cabergoline combined with hormone therapy significantly relieved pain symptoms in affected patients.

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Abstract

OBJECTIVE: The present study was to find a pathogenic evidence for dopamine agonist application in patients with endometriosis associated pain syndrome. PATIENTS AND TECHNIQUE: The study involved 227 patients of reproductive age with histologically confirmed genital endometriosis (GE) of I-III degree according to ASRM classification. The control group included 12 women with no laparoscope detected gynecologic pathology. The levels of prolactin (PRL), peripheral blood (PB), and peritoneal fluid (PF) were evaluated by chemiluminescence immune assay. The pain syndrome was measured by McGill visual analogue scale. Statistica10 program (StatSoft, Inc., Tulsa, OK) was applied for obtained data processing. RESULTS: A correlation was established between GE rate and levels of PRL and PB (Rs = 0.28, p < .05) as well as a correlation of PRL in PB and PF (Rs = 0.29, p < .05). Patients receiving cabergoline combined with hormone therapy standard schemes manifested considerable pain syndrome relief. CONCLUSIONS: PRL involvement in GE pathogenesis and more intense therapeutic impact on pain syndrome in case of combined administration of dopamine and standard hormone therapy prove cabergoline application in clinical practice.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Dopamine Agonists Endometriosis Peritoneal Diseases Adult Adult Ascitic Fluid Ascitic Fluid Ascitic Fluid Ascitic Fluid Cabergoline Cabergoline Cabergoline Dopamine Agonists Dopamine Agonists Drug Therapy, Combination Drug Therapy, Combination Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (28)

Cited by (9)

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