Efficacy of high-intensity focused ultrasound ablation for adenomyosis therapy and sexual life quality

Long L, Ling Long, Chen J, Jinyun Chen, Yu Xiong, Xiong Y, Zou M, Min Zou, Yongbin Deng, Deng Y, Li Chen, Chen L, Wang Z, Zhibiao Wang
International journal of clinical and experimental medicine · 2015 · vol. 8(7) , pp. 11701–7 · PMID:26380007 · PMC4565390 · W2413755844
Non-randomised trial OA: green CC0 ⤵ 20 in-corpus citations
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Ultrasound-guided high-intensity focused ultrasound ablation safely reduced adenomyosis lesion and uterine size, decreased symptom severity and pain, and significantly improved sexual function in patients with large uteri.

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Abstract

OBJECTIVE: The aim of this study was to evaluate the efficacy, safety and sexual life quality outcomes of ultrasound-guided high-intensity focused ultrasound (HIFU) ablations for the treatment of patients with symptomatic adenomyosis and uterine volumes >200 cm(3). METHODS: In our prospective clinical trial 47 patients with uterine volumes >200 cm(3) and symptomatic adenomyosis were treated with single treatment sessions of ultrasound-guided HIFU ablations. Beside uterus and adenomyosis lesion size reductions, outcome measures were symptom severity score (SSS), visual analogue scale (VAS) of dysmenorrhea, female sexual function index (FSFI) scores and the incidence of complications. RESULTS: In all 47 patients, the adenomyosis lesions sizes were significantly reduced 12 months after the interventions (P<0.01). The SSS and dysmenorrhea VAS scores were significantly reduced 12 months after the interventions (P<0.01) and the FSFI scores gradually improved during 12 months after the HIFU ablations (P200 cm(3) with symptomatic adenomyosis. Particularly maintaining the integrity of patients' uteri leads to significant FSFI score improvements, which were essentially reduced before the HIFU treatments.

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Outcome instruments

VAS-pain

Condition tags

adenomyosisdysmenorrhea

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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