Accuracy of Hysteroscopic Endomyometrial Biopsy in Diagnosis of Adenomyosis

Dakhly DM, Dina M R Dakhly, Abdel Moety GA, Ghada Abdel Fattah Abdel Moety, Ghada A F Abdel Moety, Saber W, Waleed Saber, Gad Allah SH, Sherine H. Gad Allah, Ahmed T. Hashem, Hashem AT, Abdel Salam LO, Lubna O E Abdel Salam, Lubna Omar El-Farouk Abdel Salam
Journal of Minimally Invasive Gynecology · 2015 · vol. 23(3) , pp. 364–371 · doi:10.1016/j.jmig.2015.11.004 · PMID:26581187 · W2174922077
Diagnostic accuracy OA: closed CC0 ⤵ 25 in-corpus citations
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This study assessed the accuracy of hysteroscopic endomyometrial biopsy in diagnosing adenomyosis compared to histopathological examination of hysterectomy specimens.

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Abstract

OBJECTIVES: To investigate the diagnostic accuracy of endomyometrial biopsy obtained via office hysteroscopy for the diagnosis of adenomyosis. STUDY DESIGN: Cross-sectional study. SETTING: Cairo University Teaching Hospital, Cairo, Egypt. PATIENTS: A total of 404 premenopausal women with symptoms clinically suggestive of having adenomyosis. INTERVENTIONS: All patients were subjected to 2-dimensional transvaginal sonography (TVS) in-office hysteroscopy examination with endomyometrial biopsy. Patients who subsequently underwent hysterectomy were included in the final analysis. MAIN MEASUREMENTS AND RESULTS: Accuracy of diagnostic modalities was represented using the terms sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy. A total of 292 patients were eligible for final analysis. Of these, 162 (55.47%) were diagnosed with adenomyosis based on hysterectomy specimens. TVS had a high sensitivity (83.95%) and a moderate specificity (60%). In contrast, endomyometrial biopsy was more specific (78.46%) than sensitive (54.32%). Hysteroscopic appearance of the endometrial cavity had low sensitivity (40.74%) and specificity (44.62%). Adding endomyometrial biopsy to TVS improved specificity (89.23%). CONCLUSION: Endomyometrial biopsy obtained via office hysteroscopy can diagnose adenomyosis with a high specificity and is recommended after TVS.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Ambulatory Surgical Procedures Ambulatory Surgical Procedures Endometrium Hysterectomy Hysteroscopy Hysteroscopy Hysteroscopy Vagina Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adult Adult Cross-Sectional Studies Cross-Sectional Studies Egypt Egypt Endometrium

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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Cited by (26)

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