Risk of appendiceal endometriosis among women with deep-infiltrating endometriosis

Janelle K. Moulder, Moulder JK, Matthew T. Siedhoff, Siedhoff MT, Kathryn Melvin, Melvin KL, Kathryn L Melvin, Elizabeth G. Jarvis, Jarvis EG, K.A. Hobbs, Kumari A Hobbs, Hobbs KA, Joanne M. Garrett, Joanne Garrett, Garrett J
International Journal of Gynecology & Obstetrics · 2017 · vol. 139(2) , pp. 149–154 · doi:10.1002/ijgo.12286 · PMID:28755505 · W2740342922
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This retrospective study found that women with deep-infiltrating endometriosis had a significantly higher risk of appendiceal endometriosis compared to those with superficial endometriosis or no endometriosis.

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Abstract

OBJECTIVE: To determine whether deep-infiltrating endometriosis (DE) carries an increased risk of appendiceal endometriosis (AppE) as compared with superficial endometriosis or no endometriosis. METHODS: In a retrospective study, data were obtained by chart review of an internal database for women who underwent coincidental appendectomy during benign gynecologic surgery between July 2009 and February 2014 at a tertiary referral center in the USA. Univariate, bivariate, and regression analyses were performed. The primary exposure was surgically documented endometriosis (DE, superficial, or no endometriosis). The primary outcome was AppE. RESULTS: Endometriosis was diagnosed for 151 (38.2%) of 395 women; 82 (54.3%) had DE. The prevalence of AppE was 13.2% (52/395) overall; 8 (11.6%) of 69 women with superficial endometriosis and 32 (39.0%) of 82 with DE were affected. Frequency of AppE was increased among women with DE, abnormal appendix appearance, and surgical indication (all P<0.001). Women with DE had a 5.9-fold (95% confidence interval [CI] 2.9-11.9) higher risk of AppE compared with women without endometriosis, controlling for appendiceal appearance and surgical indication, and a 2.7-fold (95% CI 1.2-6.2) higher risk of AppE compared with those with superficial endometriosis. CONCLUSION: Women with DE have increased risk of AppE. Coincidental appendectomy should form part of complete endometriosis excision for these patients.

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Condition tags

endometriosis

MeSH descriptors

Appendix Appendix Cecal Diseases Endometriosis Adult Adult Appendectomy Appendectomy Cecal Diseases Cecal Diseases Cecal Diseases Cecal Diseases Databases, Factual Databases, Factual Endometriosis Endometriosis Endometriosis Endometriosis Female Female

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