Absence of a relationship between endometriosis and the N314D polymorphism of galactose-1-phosphate uridyl transferase in a UK population

Ruth M. Hadfield, R M Hadfield, Manek S, S Manek, S Nakago, Nakago S, Mukherjee S, S. Mukherjee, Daniel E. Weeks, D E Weeks, H J Mardon, Mardon HJ, Barlow DH, D H Barlow, S H Kennedy, Kennedy SH
Molecular human reproduction · 1999 · vol. 5(10) , pp. 990–993 · doi:10.1093/molehr/5.10.990 · PMID:10508229 · W2116399675
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This study found no significant association between the galactose-1-phosphate uridyl transferase N314D polymorphism and endometriosis in a UK population.

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Abstract

An association between the N314D polymorphism of galactose-1-phosphate uridyl transferase and endometriosis has recently been reported in a North American population. To determine whether such an association exists in the UK population, we genotyped 148 women with sporadic (n = 91) or familial (n = 57) endometriosis, a control population of 95 male blood donors and a control group of 53 women with a normal pelvis at hysterectomy. Heterozygosity for the polymorphism was found in 14.9% (22/148) of affected women, 13.7% (13/95) of male blood donors and 11.3% (6/53) of women with a normal pelvis. There was no statistically significant difference in the frequency of the polymorphism between cases and controls in the UK population, even when the cases were divided into groups of moderate-severe disease, sporadic cases or familial cases. We conclude that the galactose-1-phosphate uridyl transferase N314D polymorphism is unlikely to be associated with endometriosis in the UK population.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Polymorphism, Genetic Polymorphism, Genetic UDPglucose-Hexose-1-Phosphate Uridylyltransferase Adult Adult Amino Acid Substitution Amino Acid Substitution Case-Control Studies Case-Control Studies Endometriosis Endometriosis Female Female Gene Frequency Gene Frequency Genotype Genotype Heterozygote

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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Cited by (31)

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