miR-142-3p is a novel regulator of cell viability and proinflammatory signalling in endometrial stroma cells
Lab / animal
OA: bronze
CC0
⤵ 17 in-corpus citations
AI-generated summary
This study investigated miR-142-3p's role in endometrial stroma cells, finding it regulates cell viability and proinflammatory signaling pathways.
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Abstract
Endometriosis is associated with severe pelvic pain and reduced fertility. Recently, it has been linked to a dysregulation of microRNAs (miRNAs), which are post-transcriptional regulators of gene expression. The functional effect of dysregulated miR-142-3p expression in endometrial stroma cells was investigated. An increased expression of miR-142-3p resulted in a significantly reduced expression of steroid sulfatase and interleukin-6-coreceptor gp130 as well as reduced interleukin-6-mediated activation of the STAT3-pathway, suggesting an effect of miR-142-3p both on steroid hormone- and cytokine-mediated signalling events. At the functional level, miR-142-3p overexpression significantly reduced cell viability (P ≤ 0.01). miR-142-3p regulation emerges as a future therapeutic strategy for endometriosis.
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References (7)
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- Interleukin-6 and other soluble factors in peritoneal fluid and endometriomas and their relation to pain and aromatase expression via openalex
- MicroRNA-regulated pathways associated with endometriosis via openalex
- Targeting of syndecan-1 by micro-ribonucleic acid miR-10b modulates invasiveness of endometriotic cells via dysregulation of the proteolytic milieu and interleukin-6 secretion via openalex
- W2082651352 via openalex
- W1993354065 via openalex
Cited by (18)
- MALAT1 accelerates proliferation and inflammation and suppresses apoptosis of endometrial stromal cells via the microRNA-142-3p/CXCR7 axis 2022
- Clues for Improving the Pathophysiology Knowledge for Endometriosis Using Plasma Micro-RNA Expression 2022
- MALAT1 accelerates proliferation and inflammation and suppresses apoptosis of endometrial stromal cells via the microRNA-142-3p/CXCR7 axis 2022
- Circulating miRNAs Related to Epithelial-Mesenchymal Transitions (EMT) as the New Molecular Markers in Endometriosis 2021
- miR-142-3p Reduces the Size, Migration and Contractility of Endometrial and Endometriotic Stromal Cells by Targeting Integrin- and Rho GTPase-related Pathways that Regulate Cytoskeletal Function 2020
- miR-142-3p Reduces the Size, Migration, and Contractility of Endometrial and Endometriotic Stromal Cells by Targeting Integrin- and Rho GTPase-Related Pathways That Regulate Cytoskeletal Function 2020
- Role of Non-coding RNAs in the Pathogenesis of Endometriosis 2020
- Plasma miRNAs Display Limited Potential as Diagnostic Tools for Endometriosis 2019
- Regulation of Proliferation and Invasion in Endometriosis 2019
- Erratum: MicroRNAs in endometriosis biological function and emerging biomarker candidates 2019
- Challenges in endometriosis miRNA studies - From tissue heterogeneity to disease specific miRNAs 2017
- MicroRNAs and Endometriosis: Distinguishing Drivers from Passengers in Disease Pathogenesis 2017
- Differential micro ribonucleic acid expression profiling in ovarian endometrioma with leuprolide acetate treatment 2016
- Pathophysiologie der Endometriose 2016
- The Important Roles of Steroid Sulfatase and Sulfotransferases in Gynecological Diseases 2016
- microRNA miR-200b affects proliferation, invasiveness and stemness of endometriotic cells by targeting ZEB1, ZEB2 and KLF4 2016
- [Research progress on the role of epithelial-mesenchymal transition in pathogenesis of endometriosis] 2016
- MiR-202 promotes endometriosis by regulating SOX6 expression 2015
Source provenance
- europepmc
- last seen: 2026-10-17T06:09:56.316927+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:15:13.843571+00:00
License: CC0
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