Endometriotic mesenchymal stem cells exhibit a distinct immune phenotype

Koippallil Gopalakrishnan Nair AR, Aghila Rani Koippallil Gopalakrishnan Nair, Hrishikesh Pandit, Warty N, Neeta Warty, Madan T, Taruna Madan
International immunology · 2014 · vol. 27(4) , pp. 195–204 · doi:10.1093/intimm/dxu103 · PMID:25416515 · W2320706517
article OA: bronze CC0 ⤵ 24 in-corpus citations
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Endometriotic mesenchymal stem cells display an altered immune phenotype with upregulated pattern recognition receptors and pro-inflammatory cytokines, potentially contributing to endometriosis pathogenesis.

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Abstract

Endometriosis is a significant debilitating gynecological problem affecting women of the reproductive age group and post-menopause. Recent reports suggest a role for endometriotic mesenchymal stem cells (ectopic MSCs) in the pathogenesis of endometriosis. To investigate the plausible mechanisms leading to the pathogenic behavior of ectopic MSCs, we compared the immunomodulatory properties of eutopic (healthy) and ectopic MSCs. We analyzed MSC phenotypes, differentiation potential, differential gene expression for an array of pattern recognition receptors (PRRs) and pro-inflammatory cytokine release along with markers of migration and angiogenesis among eutopic and ectopic MSCs. Further, alterations in immunosuppressive functions of eutopic and ectopic MSCs were examined by co-culturing them with mitogen-activated allogeneic PBMCs. Transcripts of PRRs such as all Toll-like receptors (TLR1-10), except TLR8, collectins (CL-L1, CL-P1 and CL-K1), NOD-1 and NOD-2 receptors and secreted pro-inflammatory cytokines like IL-6, IFN-γ, vascular endothelial growth factor (VEGF), epidermal growth factor and MCP-1 were significantly up-regulated in ectopic MSCs. The anti-inflammatory cytokine transforming growth factor-β showed significant down-regulation, while IL-10 showed a significant increase in ectopic MSCs. Further, ectopic MSCs showed up-regulated expression for markers of migration and angiogenesis such as matrix metalloproteinase-2 (MMP-2), MMP-3 and MMP-9 and VEGF, respectively. We report here that proliferation of PBMCs was less inhibited upon co-culture with ectopic MSCs compared with eutopic MSCs. The findings suggest that ectopic MSCs with increased levels of TLRs, collectins, pro-inflammatory cytokines and markers of migration and angiogenesis exhibit a distinct immune phenotype compared to eutopic MSCs. This distinct phenotype may be responsible for the reduced immunosuppressive property of ectopic MSCs and may be associated with the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Immunomodulation Inflammation Mesenchymal Stem Cells Adult Cell Differentiation Cell Lineage Cell Movement Cell Movement Cells, Cultured Collectins Collectins Cytokines Cytokines Cytokines Endometriosis Endometriosis Female Humans Immunomodulation

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