Peritoneal fluid concentrations of ciliary neurotrophic factor, a gp130 cytokine, in women with endometriosis

Nobuhiro Suzumori, Suzumori N, Kaoru Suzumori, Suzumori K
Gynecologic and obstetric investigation · 2003 · vol. 56(1) , pp. 51–54 · doi:10.1159/000072694 · PMID:12890930 · W1988722343
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This study measured peritoneal fluid concentrations of ciliary neurotrophic factor (CNTF) and found no correlation with endometriosis, suggesting CNTF is not involved in its pathogenesis.

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Abstract

Ciliary neurotrophic factor (CNTF) is a gp130 neuroregulatory cytokine belonging to the interleukin-6-type cytokine superfamily. Several lines of evidence suggest that the concentrations of interleukin-6 are elevated in the peritoneal fluid of endometriosis patients. To our knowledge, no study on whether this might also be the case for CNTF levels has been published previously. The CNTF concentrations in the peritoneal fluid were measured by ELISA in 51 women with (n = 31) and without (n = 20) endometriosis. Surgery was scheduled during the proliferative or the secretory phase of the menstrual cycle. CNTF was detectable in the peritoneal fluid of 43% of the women tested. The concentrations of CNTF showed no correlation with the presence of endometriosis or the phase of the menstrual cycle. We found no evidence to suggest that CNTF is involved in the pathogenesis of pelvic endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Ciliary Neurotrophic Factor Endometriosis Abdominal Pain Abdominal Pain Adult Adult Ascitic Fluid Ascitic Fluid Ciliary Neurotrophic Factor Ciliary Neurotrophic Factor Endometriosis Endometriosis Endometriosis Endometriosis Female Female Follicular Phase Follicular Phase Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (29)

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