Metabolite profiles in the peritoneal cavity of endometriosis patients and mouse models

Li Q, Qiuju Li, Ming Yuan, Xue Jiao, Miaomiao Ji, Yufei Huang, Huang Y, Li J, Jing Li, Li D, Dong Li, Wang G, Guoyun Wang
Reproductive BioMedicine Online · 2021 · vol. 43(5) , pp. 810–819 · doi:10.1016/j.rbmo.2021.06.029 · PMID:34538753 · W3178791485
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Endometriosis patients and a mouse model showed altered peritoneal fluid metabolites, including increased lysophosphatidylcholine and phosphoethanolamine derivatives, with shared metabolite sets between species.

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Abstract

RESEARCH QUESTION: Which metabolites are altered in the peritoneal cavity of women with endometriosis? Could the mouse endometriosis model simulate these alterations? DESIGN: Thirteen women with endometriosis and seven women with other benign gynaecological diseases, who underwent laparoscopic surgery, were included in this study. None had received hormonal therapy for 3 months before surgery. For the animal experiments, six and five mice were included in the endometriosis and control groups, respectively. Peritoneal fluid from the patients and peritoneal lavage fluid from the mice was collected and analysed. Non-targeted metabolomics via liquid chromatography with tandem mass spectrometry was used to identify the altered metabolites in the peritoneal fluid of endometriosis patients and mouse models. MetaboAnalyst 4.0 was used to visualize the data. RESULTS: Several metabolites in the peritoneal cavity were significantly altered in both humans and mice with endometriosis. Concentrations of lysophosphatidylcholine (LysopC) (P=0.017 in patients and P=0.041 in the mouse model) and derivatives of phosphoethanolamine (1-arachidonoyl-sn-glycero-3-phosphoethanolamine in patients, P=0.027; 1-oleoyl-sn-glycero-3-phosphoethanolamine in patients, P=0.0086; and phosphorylethanolamine in the mouse model, P=0.0027) were significantly up-regulated in both, whereas concentrations of acylcarnitines (l-palmitoylcarnitine, P=0.047; and stearoylcarnitine, P=0.029) and kynurenine (P=0.045) were significantly increased only in humans. The human and mouse samples shared three altered enriched metabolite sets. CONCLUSIONS: Women with endometriosis show an altered metabolic state in the abdominal cavity. The endometriosis mouse model shared half of the significantly altered metabolite sets found in the abdominal cavity of humans.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Metabolome Metabolome Adult Adult Animals Animals Ascitic Fluid Ascitic Fluid Ascitic Fluid Disease Models, Animal Disease Models, Animal Endometriosis Endometriosis Endometriosis Ethanolamines Ethanolamines Ethanolamines Ethanolamines

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