Perspectives of new therapies for endometriosis

Jenny Valentina Garmendia, Jenny V Garmendia, Juan Bautista De Sanctis, Juan B De Sanctis
Recent patents on endocrine, metabolic & immune drug discovery · 2012 · vol. 6(3) , pp. 218–223 · doi:10.2174/187221412802481702 · PMID:22694252 · W2320565135
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This paper reviews new pharmacological approaches and patented therapies under development to treat endometriosis, an inflammatory disease impacting fertility.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-11 · read from full text ⓘ

This paper provides an overview of endometriosis as an inflammatory extra-uterine disease involving ectopic endometrial glandular epithelial and stromal cells, highlighting downstream effects on ovarian function, oocyte quality, embryo development and implantation, and uterine function, leading to infertility or spontaneous pregnancy loss. It notes that despite a global prevalence above 10%, an effective treatment has not yet been found, and it describes newly designed and patented pharmacological approaches intended as potential future therapies. The paper’s main limitation is that it is a perspective/overview rather than presenting results from original clinical or preclinical experiments. This paper is centrally about endometriosis — it surveys perspectives on new pharmacological therapies for endometriosis.

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Abstract

Endometriosis is an inflammatory disease characterized by the presence of endometrial glandular epithelial and stromal cells growing in the extra-uterine environment. The disease affects: ovarian function, oocyte quality, embryo development and implantation, and uterine function resulting in infertility or spontaneous pregnancy loss. Even though the world's prevalence is above 10 %, an effective treatment has not yet been found. New pharmacological approaches have been designed and patented that could serve as future therapies for this disease.
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Abstract

Endometriosis is an inflammatory disease characterized by the presence of endometrial glandular epithelial and stromal cells growing in the extra-uterine environment. The disease affects: ovarian function, oocyte quality, embryo development and implantation, and uterine function resulting in infertility or spontaneous pregnancy loss. Even though the world’s prevalence is above 10 %, an effective treatment has not yet been found. New pharmacological approaches have been designed and patented that could serve as future therapies for this disease.

Keywords

Androgens, coagulation, endometriosis, fertility, GnHR, inflammation, progesterone, signal transduction. 18

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Condition tags

endometriosisinfertility

MeSH descriptors

Drug Discovery Endometriosis Women's Health Drug Design Drug Design Drug Discovery Drug Discovery Endometriosis Endometriosis Female Female Humans Humans Patents as Topic Patents as Topic Women's Health Women's Health

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (46)

Cited by (1)

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