Leiomyomatosis peritonealis disseminata coexisting with endometriosis within the same lesions: a case report with review of the literature

Ayano Toriyama, Toriyama A, Ishida M, Mitsuaki Ishida, Amano T, Tsukuru Amano, Tetsuya Nakagawa, Nakagawa T, Shouji Kaku, Kaku S, Iwai M, Muneo Iwai, Yoshida K, Keiko Yoshida, Akiko Kagotani, Kagotani A, Kentarou Takahashi, Takahashi K, Takashi Murakami, Murakami T, Okabe H, Hidetoshi Okabe
International journal of clinical and experimental pathology · 2013 · vol. 6(12) , pp. 2949–54 · PMID:24294383 · PMC3843277 · W1498043614
Review OA: closed CC0 ⤵ 9 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This case report describes the seventh instance of leiomyomatosis peritonealis disseminata (LPD) coexisting with endometriosis within the same lesions, supporting the hypothesis of a shared müllerian system origin.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Leiomyomatosis peritonealis disseminata (LPD) is an extremely rare condition, which is characterized by the presence of multiple peritoneal and subperitoneal nodules composed of bland smooth muscle cells. Albeit extremely rare, coexistence of endometriosis within LPD lesions has also reported. Herein, we report the seventh documented case of LPD coexisting with endometriosis within the same lesions and review the pathogenesis of this lesion. A 42-year-old Japanese female presented with an abdominal tumor. Computed tomography revealed a tumorous lesion in the right ovary and multiple small nodules in the abdominal cavity. Under a clinical diagnosis of ovarian cancer with peritoneal dissemination, resection of these lesions was performed. Histopathological study of the disseminated peritoneal nodules revealed proliferation of interlacing bundles of spindle cells with eosinophilic cytoplasm and bland cigar-shaped nuclei. Mitotic figures were hardly seen. The peritoneal nodules of the rectum had cystic cavities within the spindle cell bundles, and endometrial glands and stroma were present around the cystic cavities and spindle cells. The resected tissues of the ovary and cecum showed the same histopathological features. Accordingly, a diagnosis of LPD with endometriosis within the same lesions was made. A possible origin of LPD is thought to be the submesothelial multipotential stem cells, also referred to as the secondary müllerian system. The presence of endometrial tissues within LPD lesions, as seen in the present case, also support this hypothesis because endometrial tissues are also derived from the müllerian system.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Leiomyomatosis Ovarian Neoplasms Peritoneal Neoplasms Adult Adult Biomarkers, Tumor Biomarkers, Tumor Biomarkers, Tumor Biopsy Biopsy Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans Humans Immunohistochemistry

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (25)

Cited by (9)

Source provenance

europepmc
last seen: 2026-10-28T06:16:56.634860+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:12:56.342978+00:00
License: CC0 · commercial use OK