Fertility and sterility

OBJECTIVE: To determine whether increased antioxidant intake in women is associated with shorter time to pregnancy (TTP) among a cohort of couples being treated for unexplained infertility. DESIGN: Secondary data analysis of a randomized c…

OBJECTIVE: To explore the association between the genetic variant of E-cadherin gene and endometriosis-related infertility. DESIGN: Case-control study. SETTING: University hospital. PATIENT(S): Five hundred eighty-nine women with ovarian…

OBJECTIVE: To profile the long noncoding RNA (lncRNA) expression patterns in ovarian ectopic endometrial tissue compared with paired eutopic endometrial tissue. DESIGN: Genome-wide expression analysis of human tissue. SETTING: University …

OBJECTIVE: To assess healthcare resource utilization and costs during the 5 years before and 5 years after diagnosis among women with endometriosis, in comparison with women without endometriosis. DESIGN: Longitudinal, retrospective, case-…

OBJECTIVE: To report the laparoscopic management of a rare case of hematoureter due to endometriosis in a young woman with multiple genitourinary anomalies. DESIGN: Video demonstration of a surgical technique and review of genitourinary en…

OBJECTIVE: To identify a group of deliveries to mothers with indicators of subfertility (SUBFERTILITY). DESIGN: Longitudinal cohort study. SETTING: Hospital. PATIENT(S): A total of 334,152 deliveries to Massachusetts mothers in a Massach…

OBJECTIVE: To review our experience with surgical treatment of ileocecal endometriosis. DESIGN: Observational study. SETTING: Tertiary university hospital in Italy. PATIENT(S): Eight consecutive patients with infiltrating ileocecal endom…

OBJECTIVE: To determine the efficacy of image-guided drainage versus antibiotic-only treatment of pelvic abscesses. DESIGN: Retrospective cohort analysis. SETTING: An academic, inner-city medical center. PATIENT(S): Women ages 11-49, adm…

OBJECTIVE: To evaluate antimüllerian hormone (AMH) and AMH receptor II (AMHRII) mRNA and protein expression in endometrium and in ovarian or deep lesions of women with endometriosis. DESIGN: Prospective study. SETTING: University hospital…

This issue of Fertility and Sterility contains four articles by the World Endometriosis Research Foundation whose present objective is global standardization of the collection of phenotypic data and biological samples, designated as the End…

OBJECTIVE: To evaluate the effect of iron overload on nuclear factor kappa-B (NF-κB) activation in human endometrial stromal cells (ESCs). DESIGN: Experimental study. SETTING: University hospital research laboratory. PATIENT(S): Ten heal…

OBJECTIVE: To report an original technique of combined laparoscopic and transanal disc excision of lower- and mid-rectal deep endometriotic nodules. DESIGN: Video article introducing a new surgical technique. SETTING: University hospital.…

OBJECTIVE: To evaluate perioperative details, long-term outcomes, and postsurgical fertility in case of laparoscopic ureterolysis for deep endometriosis. DESIGN: Retrospective analysis of prospectively collected data. SETTING: Academic re…

OBJECTIVE: To study the role of lipoxin A4 (LXA4) in endometriosis. DESIGN: Molecular analysis in human samples and primary human endometriotic stromal cells (ESCs). SETTING: University hospital. PATIENT(S): Forty-nine premenopausal wome…

OBJECTIVE: To evaluate the expression of MIF, CD74, and COX-2 in normal, ectopic, and eutopic endometrium during the menstrual cycle and to assess MIF level in peripheral blood. DESIGN: The expressions of MIF, CD74, and COX-2 in normal, ec…

MicroRNAs (miRNAs) are a class of small non-coding RNAs estimated to regulate the translation of mRNAs in 30% of all genes in animals by inhibiting translation. Aberrant miRNA expression is associated with many human diseases, including gyn…

OBJECTIVE: To understand the rate of genetic events in patients with autism spectrum disorder (ASD) who were exposed to assisted reproduction. DESIGN: Case control study using genetics data. SETTING: Twelve collaborating data collection s…

OBJECTIVE: To evaluate whether the presence of endometriomas affects ovarian function. DESIGN: Prospective cohort study. SETTING: Infertility unit of an academic setting. PATIENT(S): Twenty-nine women undergoing an IVF cycle. INTERVENTI…

OBJECTIVE: To investigate whether lysine-specific demethylase 1 (LSD1) is aberrantly expressed in endometriomas and whether treatment with tranylcypromine, an LSD1 inhibitor, has any effect on cell viability, cell cycle, and invasiveness. …

OBJECTIVE: To investigate pathophysiologic mechanisms involved in bladder retention after surgery for rectovaginal deeply infiltrating endometriosis (DIE). DESIGN: Retrospective case study. SETTING: Tertiary referral unit. PATIENT(S): Al…

OBJECTIVE: To determine the impact of sexual intercourse around the time of implantation on the probability of achieving a pregnancy. DESIGN: Time-to-pregnancy cohort using day-specific probability of pregnancy modeling to account for inte…

OBJECTIVE: To evaluate endometrial leukemia inhibitor factor (LIF) expression as a marker of endometrial receptivity in women with unexplained infertility (UI). DESIGN: Prospective case-control study. SETTING: University-associated infert…

OBJECTIVE: To identify the expression profile and sex steroid regulation pattern of myeloid ecotropic viral integration site 1 (MEIS1) in endometrium. DESIGN: Molecular studies in human and animal tissue. SETTING: Reproductive medicine ce…