Fertility and sterility

Pain is the most evident clinical manifestation of deep infiltrating endometriosis (DIE). Several hormonal and immunologic mechanisms are markedly altered in DIE compared with superficial peritoneal and ovarian endometriosis, and may explai…

OBJECTIVE: To determine if ultrastructural tissue trauma occurs in the junctional zone in uteri in adenomyosis. DESIGN: A case-control experimental study. SETTING: Endometriosis research center. PATIENT(S): Twelve uteri with adenomyosis,…

OBJECTIVE: To collate all available evidence with respect to ultrasound techniques in the management of deep pelvic endometriosis (DPE) and compare the sensitivity and specificity of each to determine the most suitable site-specific method.…

OBJECTIVE: To assess benzophenone-type ultraviolet (UV) filter concentrations, chemicals used in sunscreen and personal care products, and semen endpoints. DESIGN: Cohort. SETTING: Not applicable. PATIENT(S): A total of 413 men provided …

OBJECTIVE: To analyze the prevalence of urinary tract endometriosis (UTE) in patients with deep infiltrating endometriosis (DIE) and to define potential criteria for preoperative workup. DESIGN: Retrospective study. SETTING: University ho…

OBJECTIVE: To examine and compare differences, if any, between industry- and nonindustry-sponsored clinical trials on endometriosis and to evaluate the effect of prior published positive preclinical results, or lack thereof, on trial status…

OBJECTIVE: To develop a model predictive of live-birth rates (LBR) and multiple birth rates (MBR) for an individual considering assisted reproduction technology (ART) using linked cycles from Society for Assisted Reproductive Technology Cli…

ObjectiveTo assess trends and outcomes of assisted hatching among assisted reproductive technology (ART) cycles.DesignRetrospective cohort analysis using National ART Surveillance System (NASS) data.SettingU.S. fertility centers reporting t…

OBJECTIVE: To investigate whether specific genetic polymorphisms in the cyclin-dependent kinase inhibitor 2B antisense RNA (CDKN2B-AS) gene and near the wingless-type MMTV integration site family member 4 (WNT4) gene are associated with end…

OBJECTIVE: To review bowel complications caused by deep endometriosis during pregnancy or in vitro fertilization (IVF). DESIGN: Three case reports and a systematic review. SETTING: A tertiary referral center for deep endometriosis surgery…

OBJECTIVE: To test the hypothesis that endometrial stromal cells (ESCs) in endometriosis exhibit increased cell motility under hypoxia. DESIGN: Prospective case-control study. SETTING: University research laboratory. PATIENT(S): Women wi…

OBJECTIVE: To elucidate the clinical profile of a concomitant diagnosis of adenomyosis in women with leiomyomas. DESIGN: Retrospective questionnaire-based study. SETTING: Academic medical center. PATIENT(S): The study sample comprised a …

OBJECTIVE: To follow-up previous studies highlighting a possible role for cytochrome P450, family 2, subfamily C, 19 (CYP2C19) in susceptibility to endometriosis by searching for additional variants in the CYP2C19 gene that may be associate…

OBJECTIVE: To analyze and compare the clinicopathological features and prognosis of ovarian clear cell carcinoma (CCC) with or without endometriosis in Chinese patients. DESIGN: Comparative study based on a retrospective review of medical …

OBJECTIVE: To compare complication rates and pain scores after oocyte pickup (OPU) in in vitro maturation (IVM) and IVF cycles. DESIGN: Retrospective cohort study. SETTING: University-affiliated ART center. PATIENT(S): One hundred eighty…

Trained fertility specialists possess a unique clinical perspective and an extensive medical and technological armamentarium to overcome reproductive dysfunction: it is their privilege and ethical duty to lead the field of reproductive surg…

OBJECTIVE: To investigate the impact of estrogen contained in oral contraceptives (OCs) on the action of progestin on ovarian endometrioma epithelial cells. DESIGN: Experimental in vitro study and immunohistochemical analysis. SETTING: Un…

OBJECTIVE: To examine the relationship between the maternal serum bisphenol A (BPA) concentration at the time of the missed menstrual cycle and miscarriage risk. DESIGN: Retrospective cohort of prospectively collected serum samples. SETTI…

OBJECTIVE: To identify the most important factor in predicting ovarian reserve after laparoscopic ovarian cystectomy and to evaluate whether there is any difference in the postoperative decline of ovarian reserve between women with endometr…

OBJECTIVE: To evaluate the effects of a prolonged duration of gonadotropin-releasing hormone agonist (GnRH-a) in pituitary down-regulation for controlled ovarian hyperstimulation (COH) on the live-birth rate in nonendometriotic women underg…

OBJECTIVE: To study follicular microenvironment in terms of free radical dynamics, oocyte quality, and assisted reproductive technology (ART) outcomes among women with (group A) and without (group B) endometriosis. DESIGN: Prospective coho…

OBJECTIVE: To investigate the effects of oxygen on the proliferation and angiogenesis of endometriosis in vivo. DESIGN: Animal studies. SETTING: Animal research facility. ANIMAL(S): Thirty-six female severe combined immunodeficiency (SCI…

OBJECTIVE: To examine the expression of CD147 in 60 human endometriosis lesions and how CD147 regulates migration and apoptosis in human uterine epithelial (HESs) cells. DESIGN: Experimental clinical study and laboratory-based investigatio…

OBJECTIVE: To describe the clinical characteristics of patients with Herlyn-Werner-Wunderlich syndrome (HWWS) and explore the relationship between an obstructive genital abnormality and pelvic endometriosis. DESIGN: Case series. SETTING: …

OBJECTIVE: To evaluate the effects of endometriomas on the regulation of early follicular development. DESIGN: Histologic analysis of prospectively collected biopsy samples. SETTING: Research unit in a university hospital. PATIENT(S): Wo…