Concurrent estrogen action was essential for maximal progestin effect in oral contraceptives

Yukiko Bono; Satoru Kyo; Tohru Kiyono; Yasunari Mizumoto; Mitsuhiro Nakamura; Yoshiko Maida; Masahiro Takakura; Hiroshi Fujiwara

doi:10.1016/j.fertnstert.2014.02.005

Concurrent estrogen action was essential for maximal progestin effect in oral contraceptives

Yukiko Bono, Satoru Kyo, Tohru Kiyono, Yasunari Mizumoto, Mitsuhiro Nakamura, Yoshiko Maida, Masahiro Takakura, Hiroshi Fujiwara

Fertility and sterility · 2014 · vol. 101(5) , pp. 1337–1343 · doi:10.1016/j.fertnstert.2014.02.005 · PMID:24656887 · W2086147144

article OA: closed CC0 ⤵ 11 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated the interplay between estrogen and progestin in oral contraceptives, finding that estrogen action is necessary for the full progestin effect.

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Condition tags

endometriosis

MeSH descriptors

Contraceptives, Oral Endometriosis Endometriosis Endometriosis Estrogens Progestins Cell Line, Transformed Contraceptives, Oral Drug Combinations Estrogens Female Humans Progestins Treatment Outcome

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References (27)

Deficient 17β-Hydroxysteroid Dehydrogenase Type 2 Expression in Endometriosis: Failure to Metabolize 17β-Estradiol<sup>1</sup> via openalex
Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis—a randomized, double-blind, multicenter, controlled trial via openalex
Endometriosis via openalex
Endometriosis and the risk of cancer with special emphasis on ovarian cancer via openalex
Estrogen metabolizing enzymes in endometrium and endometriosis via openalex
Estrogen Receptor-β, Estrogen Receptor-α, and Progesterone Resistance in Endometriosis via openalex
Inflammatory Status Influences Aromatase and Steroid Receptor Expression in Endometriosis via openalex
Long-term oral contraceptive pills and postoperative pain management after laparoscopic excision of ovarian endometrioma: a randomized controlled trial via openalex
Low-dose oral contraceptive pill for dysmenorrhea associated with endometriosis: a placebo-controlled, double-blind, randomized trial via openalex
Mechanisms of excessive estrogen formation in endometriosis via openalex
Post-operative endometriosis recurrence: a plea for prevention based on pathogenetic, epidemiological and clinical evidence via openalex
Postoperative oral contraceptive exposure and risk of endometrioma recurrence via openalex
Post-operative use of oral contraceptive pills for prevention of anatomical relapse or symptom-recurrence after conservative surgery for endometriosis via openalex
Progestogens for endometriosis: forward to the past via openalex
doi:10.1074/jbc.m407879200 via openalex
doi:10.1038/bjc.2012.26 via openalex
doi:10.1385/endo:16:3:217 via openalex
doi:10.1055/s-2001-15111 via openalex
doi:10.1016/j.mce.2005.11.041 via openalex
doi:10.1111/j.1447-0756.2009.01076.x via openalex
doi:10.1677/jme.0.0250001 via openalex
doi:10.1016/j.ejogrb.2013.11.030 via openalex
doi:10.1016/s0140-6736(04)17403-5 via openalex
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doi:10.1016/s0149-2918(02)80086-8 via openalex
doi:10.1016/j.canlet.2013.04.010 via openalex

Cited by (11)

Source provenance

europepmc: last seen: 2026-06-11T06:19:48.454388+00:00
openalex: last seen: 2026-05-11T06:09:19.794676+00:00
pubmed: last seen: 2026-05-13T22:18:35.150238+00:00

License: CC0 · commercial use OK

[1] Deficient 17β-Hydroxysteroid Dehydrogenase Type 2 Expression in Endometriosis: Failure to Metabolize 17β-Estradiol<sup>1</sup> via openalex

[2] Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis—a randomized, double-blind, multicenter, controlled trial via openalex

[3] Endometriosis via openalex

[4] Endometriosis and the risk of cancer with special emphasis on ovarian cancer via openalex

[5] Estrogen metabolizing enzymes in endometrium and endometriosis via openalex

[6] Estrogen Receptor-β, Estrogen Receptor-α, and Progesterone Resistance in Endometriosis via openalex

[7] Inflammatory Status Influences Aromatase and Steroid Receptor Expression in Endometriosis via openalex

[8] Long-term oral contraceptive pills and postoperative pain management after laparoscopic excision of ovarian endometrioma: a randomized controlled trial via openalex

[9] Low-dose oral contraceptive pill for dysmenorrhea associated with endometriosis: a placebo-controlled, double-blind, randomized trial via openalex

[10] Mechanisms of excessive estrogen formation in endometriosis via openalex

[11] Post-operative endometriosis recurrence: a plea for prevention based on pathogenetic, epidemiological and clinical evidence via openalex

[12] Postoperative oral contraceptive exposure and risk of endometrioma recurrence via openalex

[13] Post-operative use of oral contraceptive pills for prevention of anatomical relapse or symptom-recurrence after conservative surgery for endometriosis via openalex

[14] Progestogens for endometriosis: forward to the past via openalex

[15] doi:10.1074/jbc.m407879200 via openalex

[16] doi:10.1038/bjc.2012.26 via openalex

[17] doi:10.1385/endo:16:3:217 via openalex

[18] doi:10.1055/s-2001-15111 via openalex

[19] doi:10.1016/j.mce.2005.11.041 via openalex

[20] doi:10.1111/j.1447-0756.2009.01076.x via openalex

[21] doi:10.1677/jme.0.0250001 via openalex

[22] doi:10.1016/j.ejogrb.2013.11.030 via openalex

[23] doi:10.1016/s0140-6736(04)17403-5 via openalex

[24] doi:10.1016/j.fertnstert.2011.02.045 via openalex

[25] doi:10.1016/s0015-0282(02)03099-6 via openalex

[26] doi:10.1016/s0149-2918(02)80086-8 via openalex

[27] doi:10.1016/j.canlet.2013.04.010 via openalex