Elevated expression of CD147 in patients with endometriosis and its role in regulating apoptosis and migration of human endometrial cells

Aihong Jin, Jin A, Hao Chen, Chen H, Wang C, Chaoqun Wang, Lai Ling Tsang, Tsang LL, Xiaohua Jiang, Cai Z, Zhiming Cai, Hsiao Chang Chan, Chan HC, Xiaping Zhou, Zhou X
Fertility and sterility · 2014 · vol. 101(6) , pp. 1681–1687.e1 · doi:10.1016/j.fertnstert.2014.02.007 · PMID:24661733 · W1982481915
article OA: bronze CC0 ⤵ 5 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-16 ⓘ

This study investigated elevated CD147 expression in endometriosis patients and its effects on human endometrial cell apoptosis and migration.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo examine the expression of CD147 in 60 human endometriosis lesions and how CD147 regulates migration and apoptosis in human uterine epithelial (HESs) cells.DesignExperimental clinical study and laboratory-based investigation.SettingHospital and academic research center.Patient(s)Sixty women with chocolate cysts and 16 control women without endometriosis.Intervention(s)Human uterine epithelial cells were treated with anti-CD147 antibody.Main outcome measure(s)Real-time polymerase chain reaction for detecting CD147 expression in 60 human endometriosis lesions; migration assay and CellTiter 96 AQueous One Solution Cell Proliferation Assay (MTS) assay for cell functional investigation; Western blot for detecting protein levels; gelatin zymography for evaluating the activity of matrix metalloproteinase-2 (MMP-2) in cultured cells.Result(s)Expression of CD147 was significantly higher in ectopic endometrial tissues from patients with endometriosis than in normal endometrial tissues. Interference with CD147 function led to decreased migration and cell viability in HESs cells. Surprisingly, MMP-2 expression and activity were not changed after treating HESs cells with anti-CD147 antibody. Further examination revealed that immunodepletion of CD147 induced apoptosis in HESs cells, leading to the activation of caspase 3 and poly(ADP-ribose) polymerase.Conclusion(s)The results of the present study suggest that abnormally high expression of CD147 in ovarian endometriosis lesions with enhanced cell survival (reduced apoptosis) and migration, in an MMP-2-independent manner, may underlie the progression of endometriosis in humans.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Apoptosis Apoptosis Basigin Cell Movement Cell Movement Endometriosis Endometrium Epithelium Ovarian Diseases Adult Antibodies Antibodies Basigin Basigin Basigin Case-Control Studies Caspase 3 Caspase 3 Cells, Cultured Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (39)

Cited by (5)

Source provenance

europepmc
last seen: 2026-07-25T06:15:30.875455+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:18:35.150238+00:00
License: CC0 · commercial use OK