Kamran S. Moghissi

BACKGROUND: Although studies have found elevated risks of certain cancers linked to infertility, the underlying reasons remain unclear. METHODS: In a retrospective cohort study of 12,193 U.S. women evaluated for infertility between 1965 and…

ObjectiveTo evaluate the risk of ovarian cancer as related to underlying causes of infertility.DesignRetrospective observational cohort study.SettingFive large reproductive endocrinology practices.Patient(s)A total of 12,193 women evaluated…

Wayne State University/Hutzel Hospital, Detroit, Michigan Correspondence: Kamran S. Moghissi, MD, Professor, Department of Obstetrics & Gynecology, Division of Reproductive Endocrinology & Infertility, Wayne State University/Hutzel Hospital…

ObjectiveTo determine the duration of time to the recurrence of pain attributable to endometriosis after the discontinuation of treatment with danazol or a GnRH agonist (GnRH-a) in patients who have had a satisfactory response to the treatm…

A patient with long-standing secondary infertility was explored for myomectomy, at which time severe adenomyosis was found. A 6-month course of nafarelin acetate resulted in resolution of dysmenorrhea and uterine enlargement. The patient co…

Treatment with nafarelin, a gonadotropin-releasing hormone agonist, reversibly inhibits ovarian function and induces hypoestrogenemia. To determine the efficacy of such hormonal manipulation in the treatment of endometriosis, we randomly as…

This study was designed to evaluate the effectiveness of three therapeutic modalities in the management of stage I and II endometriosis. Management modalities consisted of no treatment (controls, n = 56); oral medroxyprogesterone acetate (M…

Over the past three decades, medical management of endometriosis has included high-dose synthetic estrogen, diethylstilbestrol, androgens, progestins (with or without estrogen), danazol, a synthetic derivative of 17-ethinyl testosterone, an…

Efficacy of oral medroxyprogesterone acetate (MPA) was assessed in 35 women with an established diagnosis of endometriosis (33 pelvic and 2 abdominal). MPA was given in a dosage of 30 mg daily for 90 days. Results indicated improvement or r…

In this study of 132 infertile couples, findings with hysterosalpingography (HSG) were compared with those observed at subsequent culdoscopy or laparoscopy. Both procedures correctly revealed normal tubes in 29% of the subjects and identica…