Hiroshi Kobayashi
No ORCID on file
· 130 papers in corpus
· active 1987-2026
Study types
- article 67
- review 54
- other 8
- book-chapter 1
Condition tags
- endometriosis 114
- endometrioma 28
- adenomyosis 27
- infertility 16
- dysmenorrhea 7
- die_deep_infiltrating 4
- chronic_pelvic_pain 3
Top journals
Frequent coauthors
- Yoshihiko Yamada 37
- Hiroshi Shigetomi 34
- Shogo Imanaka 31
- Chiharu Yoshimoto 22
- Naoki Kawahara 20
- Ryuji Kawaguchi 18
- Shoji Haruta 17
- Naoto Furukawa 15
- Shozo Yoshida 15
- Yasuhito Tanase 14
article
2019
AIM: Expression of CD44 variant isoforms (CD44v) promotes the synthesis of reduced glutathione and contributes to reactive oxygen species defense through up-regulation of the intracellular antioxidant. The aim of the study was to investigat…
article
2019
BACKGROUND AND OBJECTIVE: Atypical endometriosis is reported to possess a precancerous potential attributed to premalignant changes characterized by cytological atypia and architecture proliferation. Although the coexistence of atypical end…
other
2019
BACKGROUND: Common cancerous histological types associated with endometriosis are clear cell carcinoma (CCC) and endometrioid carcinoma (EC). CCC is regarded as an aggressive, chemoresistant histological subtype. Magnetic resonance imaging …
article
2019
Endometriosis is a precancerous condition for endometriosis‑associated ovarian cancer (EAOC). In the present study, conventional magnetic resonance imaging (MRI) and MR relaxometry were used to examine a case of clear cell carcinoma that ar…
review
2019
Adenomyosis is a common gynecologic disorder defined by the presence of endometrial glands and stroma within the uterine myometrium. This review focusses on: (1) current understanding of cellular and molecular mechanisms of adenomyosis-rela…
article
2019
The aim of this review article was to assess the potential link between somatic driver mutations in endometriosis and the pathogenesis of fibrotic processes in other organ systems. This review presents the results of a PubMed literature sea…
article
2019
We aimed to retrospectively analyze the risk factors of a continuous dienogest (DNG) therapy for serious unpredictable bleeding in patients with symptomatic adenomyosis. This is a retrospective study based on data extracted from medical rec…
article
2018
We herein report a case of clear cell carcinoma arising from endometriosis in the groin in a 53‐year‐old woman. The findings of MRI and FDG/PET‐CT indicated a malignant tumor, and surgical biopsy confirmed adenocarcinoma of the female genit…
article
2018
article
2018
The present study aimed to evaluate the levels of oxidative stress and antioxidant markers in benign endometrioma (OE) and its malignant transformation [endometriosis‑associated ovarian cancer (EAOC)] by measuring 8‑hydroxy‑2‑deoxyguanosine…
article
2018
The aim of the present single-center retrospective study was to investigate the discrimination of malignant transformation from ovarian endometrioma (OE) using a near‑infrared approach ex vivo. Cystic fluid samples were collected from patie…
review
2018
In the present study, we summarize the role of the shared and independent (epi)genetic background between endometrioid carcinoma (EC) and clear cell carcinoma (CCC), two histological subtypes of endometriosis-associated ovarian cancer (EAOC…
article
2018
Endometriosis-associated ovarian cancer (EAOC) is a rare entity and has highly variable morphological presentations. Mural nodules can be seen in EAOC and benign ovarian endometrioma (OE), which causes a diagnostic dilemma. The differential…
article
2017
PURPOSE: Mural nodules and papillary projections can be seen in benign ovarian endometriosis (OE) and malignant transformation of OE (endometriosis-associated ovarian cancer [EAOC]), which can pose a challenging diagnostic dilemma to clinic…
article
2017
article
2017
OBJECTIVE: To estimate the phenotypic characterization of fibrotic process in adenomyosis occurring at the inner or the outer myometrium. METHODS: Eight cases of adenomyosis occurring at the inner myometrium (Subtype I) and 10 cases of aden…
article
2017
review
2017
Aberrant DNA methylation and histone modification are associated with an increased risk of reproductive disorders such as endometriosis. However, a cause-effect relationship between epigenetic mechanisms and endometriosis development has no…
article
2016
BACKGROUND: There is currently no reliable serum biomarker for ovarian clear cell carcinoma (CCC), a highly lethal histological subtype of epithelial ovarian cancer (EOC). Previously, using a proteome-based approach, we identified tissue fa…
article
2016
The aim of the present study was to assess the relative concentrations of hemoglobin (Hb) species in endometriosis as a possible indicator of malignancy. Electronic absorption spectroscopy was employed to quantify the Hb species present in …
article
2016
article
2016
PURPOSE: Heme and iron accumulation due to repeated hemorrhage in endometriosis may contribute to a pivotal role in carcinogenesis. We evaluate the clinical application of MR relaxometry in a series of ovarian endometriosis (OE) and endomet…
article
2015
In clear cell carcinoma of the ovary, chemoresistance frequently results in treatment failure. The present study aimed to review the potential association of transcription factor hepatocyte nuclear factor (HNF)-1β with cell cycle checkpoint…
article
2015
OBJECTIVE: The purpose of this study was to investigate cyst fluid levels of total iron, heme iron and free iron in benign endometriotic cysts and endometriosis-associated ovarian cancer (EAOC) and to demonstrate the significance of these b…
review
2015
The aim of the present review was to illustrate how dysregulation of hormonal signaling regulates expressional changes of spatially associated genes in endometriosis. From a multi‑platform endometriosis dataset, an integrated analysis was p…