Transverse Relaxation Rate of Cyst Fluid Can Predict Malignant Transformation of Ovarian Endometriosis

Chiharu Yoshimoto, Junko Takahama, Takuya Iwabuchi, Masato Uchikoshi, Hiroshi Shigetomi, Hiroshi Kobayashi
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2016 · vol. 16(2) , pp. 137–145 · doi:10.2463/mrms.mp.2016-0028 · PMID:27646154 · W2519434689
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Abstract

PURPOSE: Heme and iron accumulation due to repeated hemorrhage in endometriosis may contribute to a pivotal role in carcinogenesis. We evaluate the clinical application of MR relaxometry in a series of ovarian endometriosis (OE) and endometriosis-associated ovarian cancer (EAOC). MATERIALS AND METHODS: A prospective study of diagnostic accuracy was conducted among 82 patients (67 OE and 15 EAOC) to compare MR relaxometry and biochemical measurement of cyst fluid total iron concentration. Transverse relaxation rate R2 value was determined using a single-voxel, multi-echo MR sequence (HISTO) by a 3T-MR system. Phantom experiments were also performed to assess the correlation between the ex vivo R2 values and total iron concentrations. RESULTS: Both the results of phantom experiments and in vivo human data confirmed that in vivo R2 values were highly correlated with total iron concentrations. Compared to OE, EAOC exhibit decreased in vivo R2 values and total iron levels, regardless of their age, menopausal status and cyst size. The use of in vivo R2 values retained excellent accuracy in distinguishing EAOC versus OE (sensitivity and specificity: 86% and 94%). CONCLUSIONS: We have demonstrated that MR relaxometry provides a noninvasive predictive tool to discriminate between EAOC and OE.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cell Transformation, Neoplastic Cyst Fluid Endometriosis Magnetic Resonance Imaging Ovarian Neoplasms Adult Aged Cell Transformation, Neoplastic Cell Transformation, Neoplastic Cohort Studies Cyst Fluid Endometriosis Endometriosis Endometriosis Female Humans Iron Iron Middle Aged Ovarian Neoplasms

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