Sachiko Matsuzaki

Endometriosis, a common gynecological disorder that causes infertility and pelvic pain, is defined as the presence of endometrial glands and stroma within extra-uterine sites. However, despite extensive studies its etiology and pathogenesis…

BACKGROUND: Recent studies have indicated new physiological roles for erythropoietin (Epo) unrelated to erythropoiesis. We previously demonstrated that the Epo concentrations in peritoneal fluid from patients with stage I endometriosis were…

To estimate the probability of pregnancy in infertile women with endometriosis, two series of multivariate analyses were performed in Tohoku University Hospital. In the first series, from 1993 to 1997, 103 patients participated. The Cox pro…

ObjectiveTo quantify and compare messenger RNA (mRNA) levels of ER-alpha and ER-beta among ovarian endometriotic cysts and red and black peritoneal endometriotic lesions.DesignProspective study.SettingUniversity hospital.Patient(s)Patients …

ObjectiveThis study was undertaken to evaluate the immunohistochemical expression of the cell cycle inhibitor p27Kip1 and proliferation marker Ki67 in peritoneal endometriosis and eutopic endometrium.DesignProspective study.SettingUniversit…

ObjectiveTo investigate the angiogenic status of the vasculature in peritoneal endometriosis based on macroscopic appearance.DesignProspective study.SettingUniversity hospital.Patient(s)Patients with peritoneal endometriosis.Intervention(s)…

ObjectiveTo evaluate the expression of estrogen receptor (ER)-alpha and ER-beta messenger RNA (mRNA) in ovarian endometriosis.DesignProspective study.SettingUniversity hospital.Patient(s)Patients with endometriosis and patients with uterine…

We report a case of endomyometriosis arising in the left uterosacral ligament of a 29-year-old woman. The central cavity of the uterine-like mass was lined by pseudo-stratified columnar epithelium and endometrial stroma. The wall of the cys…

ObjectiveTo quantify messenger RNA (mRNA) levels of the two estrogen receptor isoforms, estrogen receptor-alpha (ER-alpha) and estrogen receptor-beta (ER-beta) in the eutopic endometrium and ovarian endometriotic cysts.DesignProspective stu…

OBJECTIVE: To evaluate the degree of fibrosis in the stroma of peritoneal endometriosis, according to the macroscopic appearance. METHODS: Red and black lesions of peritoneal endometriosis were collected and type-I collagen was immunohistoc…

We evaluated angiogenesis in eutopic endometrium and ectopic endometrium from patients with endometriosis. Microvessels were identified by immunohistochemistry using anti-von-Willebrand factor antibody and vascular parameters were measured …

PROBLEM: Factors regulating fibrosis in peritoneal endometriosis are poorly understood. We hypothesized that mast cell proteases may play a role in the process of fibrosis in peritoneal endometriosis. As the first step in examining the poss…